# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1821154 | B | Modulation of human PPARalpha-LBD expressed in african green monkey COS7 cells co-transfected with Gal4 assessed as activation of transactivation activity at 10 uM by luciferase assay | Homo sapiens | 16 | ALA1817621 | cell-based format | Scientific Literature | |
2. | ALA1821155 | B | Modulation of human PPARdelta-LBD expressed in african green monkey COS7 cells co-transfected with Gal4 assessed as activation of transactivation activity at 10 uM by luciferase assay | Homo sapiens | 16 | ALA1817621 | cell-based format | Scientific Literature | |
3. | ALA1821156 | B | Modulation of human PPARgamma-LBD expressed in african green monkey COS7 cells co-transfected with Gal4 assessed as activation of transactivation activity at 10 uM by luciferase assay | Homo sapiens | 4 | ALA1817621 | cell-based format | Scientific Literature | |
4. | ALA1821160 | B | Modulation of gamma-secretase expressed in CHO cells co-expressing human APP and wild type human presenilin-1 assessed as inhibition of amyloid beta42 production by ELISA | 21 | ALA1817621 | cell-based format | Scientific Literature | ||
5. | ALA1821161 | B | Modulation of gamma-secretase expressed in CHO cells co-expressing human APP and wild type human presenilin-1 assessed as increase of amyloid beta38 production by ELISA | 17 | ALA1817621 | cell-based format | Scientific Literature | ||
6. | ALA1821162 | B | Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid at 10 uM by HPLC analysis | Ovis aries | 16 | ALA1817621 | single protein format | Scientific Literature | |
7. | ALA1821163 | B | Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid at 10 uM by HPLC analysis | Homo sapiens | 16 | ALA1817621 | single protein format | Scientific Literature | |
8. | ALA1821168 | A | Cytotoxicity against CHO cells expressing human APP and wild type human presenilin-1 assessed as reduction of cell viability up to 40 uM after 24 hrs by Alamar blue assay | Cricetulus griseus | 18 | ALA1817621 | cell-based format | Scientific Literature | |
9. | ALA2174545 | B | Selectivity ratio of IC50 for human recombinant 5-lipoxygenase in cell-free system to IC50 for 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated PMNL | Homo sapiens | 5 | ALA2169781 | single protein format | Scientific Literature | |
10. | ALA2174546 | A | Cytotoxicity in human polymorphonuclear leukocytes assessed as cell viability at 10 uM after 24 hrs by MTT assay | Homo sapiens | 14 | ALA2169781 | cell-based format | Scientific Literature | |
11. | ALA2174547 | B | Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challenge | Homo sapiens | 36 | ALA2169781 | single protein format | Scientific Literature | |
12. | ALA2172850 | B | Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC analysis | Homo sapiens | 36 | ALA2169781 | microsome format | Scientific Literature | |
13. | ALA2173193 | B | Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as residual activity by measuring reduction of PGE2 formation from PGH2 at 10 uM after 15 mins by RP-HPLC analysis | Homo sapiens | 9 | ALA2169781 | microsome format | Scientific Literature | |
14. | ALA2173194 | B | Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid after 5 to 10 mins by HPLC analysis | Homo sapiens | 35 | ALA2169781 | single protein format | Scientific Literature | |
15. | ALA2173195 | B | Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid assessed as remaining activity at 10 uM after 5 to 10 mins by HPLC analysis | Homo sapiens | 14 | ALA2169781 | single protein format | Scientific Literature | |
16. | ALA2173197 | B | Inhibition of ovine COX-1 mediated formation of 12-HHT from arachidonic acid assessed as remaining activity at 10 uM after 5 mins by HPLC analysis | Ovis aries | 15 | ALA2169781 | single protein format | Scientific Literature | |
17. | ALA2173198 | B | Inhibition of human recombinant COX-2 mediated formation of 12-HHT from arachidonic acid assessed as remaining activity at 10 uM after 5 mins by HPLC analysis | Homo sapiens | 15 | ALA2169781 | single protein format | Scientific Literature |