# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1820080 | Binding | Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillation counting | Rattus norvegicus | 23 | ALA1817583 | single protein format | Scientific Literature | |
2. | ALA1820081 | Physicochemical | Aqueous solubility of the compound in buffer at pH 1.2 | 8 | ALA1817583 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA1820082 | Functional | Inhibition of cholesterol synthesis in rat hepatocytes assessed as formation of cholesterol using [14C]mevalonolactone as substrate after 1 hr by liquid scintillation counting | Rattus norvegicus | 15 | ALA1817583 | cell-based format | Scientific Literature | |
4. | ALA1820083 | Physicochemical | Aqueous solubility of the compound in buffer at pH 6.8 | 8 | ALA1817583 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA1820084 | ADME | Efflux ratio of permeability in human Caco2 cells | Homo sapiens | 8 | ALA1817583 | cell-based format | Scientific Literature | |
6. | ALA1820472 | Functional | Reduction in total serum cholesterol level in syrian hamster at 100 mg/kg, po bid for 14 days | Mesocricetus auratus | 2 | ALA1817583 | organism-based format | Scientific Literature | |
7. | ALA1820473 | Functional | Reduction in total serum triglyceride level in syrian hamster at 100 mg/kg, po bid for 14 days | Mesocricetus auratus | 2 | ALA1817583 | organism-based format | Scientific Literature | |
8. | ALA1820474 | Functional | Reduction in serum non-HDL cholesterol level in marmosets at 100 mg/kg/day, po for 5 days | marmosets | 1 | ALA1817583 | organism-based format | Scientific Literature | |
9. | ALA1820475 | Functional | Reduction in serum HDL cholesterol level in marmosets at 100 mg/kg/day, po for 5 days | marmosets | 1 | ALA1817583 | organism-based format | Scientific Literature | |
10. | ALA1820476 | Functional | Reduction in serum triglyceride levels in marmosets at 100 mg/kg/day, po for 5 days | marmosets | 1 | ALA1817583 | organism-based format | Scientific Literature |