# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1826225 | B | Inhibition of porcine kidney APN using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysis | Sus scrofa | 12 | ALA1821575 | single protein format | Scientific Literature | |
2. | ALA1826226 | B | Inhibition of bovine kidney cytosolic leucine aminopeptidase using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysis | Bos taurus | 12 | ALA1821575 | single protein format | Scientific Literature | |
3. | ALA1826227 | B | Inhibition of Aeromonas proteolytica aminopeptidase using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysis | Vibrio proteolyticus | 12 | ALA1821575 | single protein format | Scientific Literature | |
4. | ALA2352979 | F | Antiangiogenic activity against human A673 cells xenografted in athymic nude mouse assessed as reduction in microvessel density at 40 mg/kg, ip administered as single dose measured on day 26 relative to control | Homo sapiens | 1 | ALA2346567 | organism-based format | Scientific Literature | |
5. | ALA2352981 | F | Antitumor activity against human A673 cells xenografted in athymic nude mouse assessed as tumor growth inhibition at 40 mg/kg, ip administered as single dose measured on day 26 relative to control | Homo sapiens | 1 | ALA2346567 | organism-based format | Scientific Literature | |
6. | ALA2352983 | T | Toxicity in Swiss nude mouse assessed as convulsions at 100 mg/kg, ip administered once every 3 days 4 times measured post second-dose | Mus musculus | 1 | ALA2346567 | organism-based format | Scientific Literature | |
7. | ALA2352985 | T | Toxicity in Swiss nude mouse assessed as catalepsy at 70 mg/kg, ip administered once every 3 days 8 times measured post second-dose | Mus musculus | 1 | ALA2346567 | organism-based format | Scientific Literature | |
8. | ALA2352986 | T | Toxicity in Swiss nude mouse assessed as adverse effects at 40 mg/kg, ip administered once every 3 days 8 times measured after 29 days | Mus musculus | 2 | ALA2346567 | organism-based format | Scientific Literature | |
9. | ALA2352988 | P | Chemical stability of the compound in DMSO solution at 5 mg/ml after 20 days at 25 degC | 2 | ALA2346567 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA2352989 | T | Toxicity in Swiss nude mouse assessed as transient body weight loss at 100 mg/kg, ip measured up to 2 days relative to control | Mus musculus | 1 | ALA2346567 | organism-based format | Scientific Literature | |
11. | ALA2352990 | P | Chemical stability of the compound in DMSO solution at 5 mg/ml after 20 days at -20 degC | 2 | ALA2346567 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA2352991 | P | Chemical stability of the compound in DMSO solution at 5 mg/ml after 20 days at 4 degC | 2 | ALA2346567 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA2353211 | F | Antimigratory activity against human HUVEC cells assessed as inhibition of VEGF-induced migration at 0.1 uM after 16 hrs by Boyden chamber assay | Homo sapiens | 1 | ALA2346567 | cell-based format | Scientific Literature | |
14. | ALA2353212 | F | Antimigratory activity against human Caco2/TC7 cells after 16 hrs by wound healing assay | Homo sapiens | 2 | ALA2346567 | cell-based format | Scientific Literature | |
15. | ALA2353213 | F | Antimigratory activity against human HUVEC cells after 16 hrs by wound healing assay | Homo sapiens | 2 | ALA2346567 | cell-based format | Scientific Literature | |
16. | ALA2353216 | F | Antimigratory activity against human HUVEC cells at 0.1 to 1 uM after 16 hrs by wound healing assay | Homo sapiens | 2 | ALA2346567 | cell-based format | Scientific Literature | |
17. | ALA2353217 | F | Antimigratory activity against human Caco2/TC7 cells up to 1 uM after 16 hrs by wound healing assay | Homo sapiens | 1 | ALA2346567 | cell-based format | Scientific Literature | |
18. | ALA2353220 | F | Antiangiogenic activity against human HUVEC cells assessed as inhibition of capillary tube formation at 1 uM after 24 hrs by phase contrast microscopic analysis | Homo sapiens | 2 | ALA2346567 | cell-based format | Scientific Literature | |
19. | ALA2353221 | A | Cytotoxicity against human HUVEC cells assessed as concentration of compound causing 50% cell death after 24 hrs | Homo sapiens | 3 | ALA2346567 | cell-based format | Scientific Literature | |
20. | ALA2353224 | B | Inhibition of MMP12 (unknown origin) up to 50 uM | Homo sapiens | 3 | ALA2346567 | single protein format | Scientific Literature |