# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2034076 | B | Inhibition of full-length B-raf V600E mutant | Homo sapiens | 25 | assay format | Scientific Literature | ||
2. | ALA2034077 | B | Inhibition of B-raf V600E mutant-mediated Erk phosphorylation in human Malme3 cells | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
3. | ALA2034078 | B | Inhibition of B-raf V600E mutant at 1 uM | Homo sapiens | 2 | assay format | Scientific Literature | ||
4. | ALA2034079 | B | Inhibition of wild type B-raf at 1 uM | 2 | single protein format | Scientific Literature | |||
5. | ALA2034080 | B | Inhibition of wild type c-Raf at 1 uM | 2 | single protein format | Scientific Literature | |||
6. | ALA2034081 | B | Inhibition of FGR at 1 uM | 2 | single protein format | Scientific Literature | |||
7. | ALA2034082 | B | Inhibition of PTK6 at 1 uM | 2 | single protein format | Scientific Literature | |||
8. | ALA2034083 | B | Inhibition of SRMS at 1 uM | 2 | single protein format | Scientific Literature | |||
9. | ALA2034087 | P | Aqueous solubility of the compound at pH 6.5 | 3 | small-molecule physicochemical format | Scientific Literature | |||
10. | ALA2034088 | P | Aqueous solubility of the compound at pH 7.4 | 3 | small-molecule physicochemical format | Scientific Literature | |||
11. | ALA2034089 | A | AUC in mouse at 30 mg/kg, po administered with 40/10/50 volume of PEG400/EtOH/H2O solution | Mus musculus | 2 | organism-based format | Scientific Literature | ||
12. | ALA2034090 | A | Clearance in mouse at 2.5 mg/kg, iv | Mus musculus | 2 | organism-based format | Scientific Literature | ||
13. | ALA2034091 | A | Oral bioavailability in mouse at 30 mg/kg | Mus musculus | 2 | organism-based format | Scientific Literature | ||
14. | ALA2034092 | A | Volume of distribution in mouse at 2.5 mg/kg, iv and 30 mg/kg, po | Mus musculus | 2 | organism-based format | Scientific Literature | ||
15. | ALA2034093 | P | Aqueous solubility of the compound at pH 1.2 | 2 | small-molecule physicochemical format | Scientific Literature | |||
16. | ALA2034094 | A | AUC in mouse at 30 mg/kg, po administered with 1% methylcellulose/0.5% Tween 80 in water | Mus musculus | 2 | organism-based format | Scientific Literature | ||
17. | ALA2049552 | F | Antitumor activity against human COLO205 cells expressing B-raf V600E mutant xenografted in po dosed NCr nude mouse assessed as decrease in tumor volume administered once daily for 21 days measured twice a week up to 21 days | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
18. | ALA2050455 | B | Inhibition of His6X-tagged human B-raf V600E mutant expressed in baculovirus infected insect cells coexpressing CSC37 using [gamma33P]ATP after 60 mins by scintillation counting | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
19. | ALA2050456 | B | Inhibition of B-raf V600E mutant-mediated Erk phosphorylation in human MALM-3M cells by fluorometric analysis | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
20. | ALA2050457 | P | Dissociation constant, pKa of the compound at acidic pH | 3 | small-molecule physicochemical format | Scientific Literature |