# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1827789 | F | Immunomodulatory effect in human THP1 cells assessed as increase in LPS-induced TNF-alpha release at 20.2 uM after 24 hrs by sandwich ELISA relative to LPS | Homo sapiens | 16 | ALA1821722 | cell-based format | Scientific Literature | |
2. | ALA1827795 | F | Immunomodulatory effect in human PBMC cells assessed as increase in LPS-induced TNFalpha release at 20.2 uM after 18 hrs by flow cytometry analysis relative to LPS | Homo sapiens | 8 | ALA1821722 | cell-based format | Scientific Literature | |
3. | ALA1827798 | F | Immunomodulatory effect in human PBMC cells assessed as LPS-induced IL1-beta release at 20.2 uM after 18 hrs by flow cytometry analysis relative to LPS | Homo sapiens | 8 | ALA1821722 | cell-based format | Scientific Literature | |
4. | ALA1827891 | A | Cytotoxicity against human THP1 cells assessed as LDH release at 20.2 uM | Homo sapiens | 15 | ALA1821722 | cell-based format | Scientific Literature | |
5. | ALA1827892 | A | Cytotoxicity against human PBMC assessed as LDH release at 20.2 uM | Homo sapiens | 15 | ALA1821722 | cell-based format | Scientific Literature | |
6. | ALA1827893 | T | Toxicity in human THP1 cells assessed TNF-alpha release at 20.2 uM after 24 hrs by sandwich ELISA | Homo sapiens | 15 | ALA1821722 | cell-based format | Scientific Literature | |
7. | ALA1828059 | F | Immunosuppressive effect in human PBMC cells assessed as increase in PMS/ionomycin-induce TNFalpha release at 20.2 uM after 18 hrs by flow cytometry analysis relative to PMA and ionomycin | Homo sapiens | 2 | ALA1821722 | cell-based format | Scientific Literature | |
8. | ALA1828060 | F | Immunosuppressive effect in human PBMC cells assessed as increase in PMS/ionomycin-induce IL-10 release at 20.2 uM after 18 hrs by flow cytometry analysis relative to PMA and ionomycin | Homo sapiens | 2 | ALA1821722 | cell-based format | Scientific Literature | |
9. | ALA1828061 | F | Immunosuppressive effect in human PBMC cells assessed as increase in PMS/ionomycin-induce IL-6 release at 20.2 uM after 18 hrs by flow cytometry analysis relative to PMA and ionomycin | Homo sapiens | 2 | ALA1821722 | cell-based format | Scientific Literature | |
10. | ALA1828062 | F | Immunosuppressive effect in human PBMC cells assessed as increase in PMS/ionomycin-induce IL1-beta release at 20.2 uM after 18 hrs by flow cytometry analysis relative to PMA and ionomycin | Homo sapiens | 2 | ALA1821722 | cell-based format | Scientific Literature | |
11. | ALA1828063 | F | Immunosuppressive effect in human PBMC cells assessed as increase in PMS/ionomycin-induce IL-8a release at 20.2 uM after 18 hrs by flow cytometry analysis relative to PMA and ionomycin | Homo sapiens | 2 | ALA1821722 | cell-based format | Scientific Literature | |
12. | ALA1828064 | F | Immunomodulatory effect in human PBMC cells assessed as decrease in LPS-induced IL-10 release at 20.2 uM after 18 hrs by flow cytometry analysis relative to LPS | Homo sapiens | 3 | ALA1821722 | cell-based format | Scientific Literature | |
13. | ALA1828065 | F | Immunomodulatory effect in human PBMC cells assessed as decrease in LPS-induced IL-6 release at 20.2 uM after 18 hrs by flow cytometry analysis relative to LPS | Homo sapiens | 3 | ALA1821722 | cell-based format | Scientific Literature | |
14. | ALA1828066 | F | Immunomodulatory effect in human PBMC cells assessed as decrease in LPS-induced IL-8a release at 20.2 uM after 18 hrs by flow cytometry analysis relative to LPS | Homo sapiens | 4 | ALA1821722 | cell-based format | Scientific Literature | |
15. | ALA3803966 | B | Agonist activity at NOD2 receptor (unknown origin) expressed in HEK-Blue cells assessed as NF-kappaB transcriptional activity at 20 uM after 18 hrs by secreted embryonic alkaline phosphatase reporter gene assay relative to untreated control | Homo sapiens | 20 | ALA3797113 | cell-based format | Scientific Literature | |
16. | ALA3803967 | B | Agonist activity at NOD1 receptor (unknown origin) expressed in HEK-Blue cells assessed as NF-kappaB transcriptional activity at 20 uM after 18 hrs by secreted embryonic alkaline phosphatase reporter gene assay | Homo sapiens | 20 | ALA3797113 | cell-based format | Scientific Literature | |
17. | ALA3803969 | A | Cytotoxicity against NOD2 expressing HEK-Blue cells assessed as residual metabolic activity at 20 uM after 18 hrs by MTS assay relative to control | Homo sapiens | 18 | ALA3797113 | cell-based format | Scientific Literature |