| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1815983 | F | Antagonist activity at Pseudomonas aeruginosa PAO1 MW1 (pUM15) LasR assessed as inhibition of OdDHL-induced quorum sensing activation at 10 uM after 8 hrs by beta-galactosidase reporter gene assay relative to untreated control | Pseudomonas aeruginosa PAO1 | 21 | assay format | Scientific Literature | ||
| 2. | ALA1816007 | F | Agonist activity at Pseudomonas aeruginosa PAO1 MW1 (pUM15) LasR at 10 uM after 8 hrs by beta-galactosidase reporter gene assay relative to OdDHL | Pseudomonas aeruginosa PAO1 | 21 | assay format | Scientific Literature | ||
| 3. | ALA1816008 | F | Antagonist activity at Escherichia coli DH5alpha (pJN105L + pSC11) LasR assessed as inhibition of OdDHL-induced quorum sensing activation at 10 uM after 8 hrs by beta-galactosidase reporter gene assay relative to untreated control | Escherichia coli DH5[alpha] | 21 | assay format | Scientific Literature | ||
| 4. | ALA1816009 | F | Agonist activity at Escherichia coli DH5alpha (pJN105L + pSC11) LasR at 10 uM after 8 hrs by beta-galactosidase reporter gene assay relative to OdDHL | Escherichia coli DH5[alpha] | 21 | assay format | Scientific Literature | ||
| 5. | ALA1816011 | F | Agonist activity at Escherichia coli DH5alpha (pJN105L + pSC11) LasR after 8 hrs by beta-galactosidase reporter gene assay relative to OdDHL | Escherichia coli DH5[alpha] | 5 | assay format | Scientific Literature | ||
| 6. | ALA1816064 | F | Agonist activity at Pseudomonas aeruginosa PAO1 MW1 (pUM15) LasR after 8 hrs by beta-galactosidase reporter gene assay relative to OdDHL | Pseudomonas aeruginosa PAO1 | 3 | assay format | Scientific Literature | ||
| 7. | ALA1816065 | F | Antagonist activity at Vibrio fischeri ESI 114 (delta-LuxI) LuxR assessed as inhibition of OdDHL-induced quorum sensing activation at 10 uM after 8 hrs by beta-galactosidase reporter gene assay relative to untreated control | Aliivibrio fischeri | 21 | assay format | Scientific Literature | ||
| 8. | ALA1816066 | F | Agonist activity at Vibrio fischeri ESI 114 (delta-LuxI) LuxR at 10 uM after 8 hrs by beta-galactosidase reporter gene assay relative to OdDHL | Aliivibrio fischeri | 21 | assay format | Scientific Literature | ||
| 9. | ALA1816067 | F | Antagonist activity at Agrobacterium tumefaciens WCF (pCF372) TraR assessed as inhibition of OdDHL-induced quorum sensing activation at 10 uM after 8 hrs by beta-galactosidase reporter gene assay relative to untreated control | Agrobacterium tumefaciens | 21 | assay format | Scientific Literature | ||
| 10. | ALA1816068 | F | Agonist activity at Agrobacterium tumefaciens WCF (pCF372) TraR at 10 uM after 8 hrs by beta-galactosidase reporter gene assay relative to OdDHL | Agrobacterium tumefaciens | 21 | assay format | Scientific Literature | ||
| 11. | ALA1816069 | F | Antagonist activity at Vibrio fischeri ESI 114 (delta-LuxI) LuxR assessed as inhibition of OdDHL-induced quorum sensing activation after 8 hrs by beta-galactosidase reporter gene assay | Aliivibrio fischeri | 7 | assay format | Scientific Literature | ||
| 12. | ALA1816071 | F | Antagonist activity at Agrobacterium tumefaciens WCF (pCF372) TraR assessed as inhibition of OdDHL-induced quorum sensing activation after 8 hrs by beta-galactosidase reporter gene assay | Agrobacterium tumefaciens | 4 | assay format | Scientific Literature | ||
| 13. | ALA1816073 | P | Hydrolytic stability of the compound in Luria-Bertani medium containing Pseudomonas aeruginosa PA01 MW1 (pUM15) assessed as half life by measuring YFP fluorescence | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 14. | ALA1816074 | A | Growth inhibition of Pseudomonas aeruginosa PAO1 MW1 (pUM15) at 10 uM after 4 to 16 hrs | Pseudomonas aeruginosa | 21 | organism-based format | Scientific Literature | ||
| 15. | ALA1816103 | A | Growth inhibition of Escherichia coli DH5alpha (pJN105L + pSC11) at 10 uM after 4 to 16 hrs | Escherichia coli | 21 | organism-based format | Scientific Literature | ||
| 16. | ALA1816104 | A | Growth inhibition of Vibrio fischeri ESI 114 (delta-LuxI) at 10 uM after 4 to 16 hrs | Aliivibrio fischeri | 21 | organism-based format | Scientific Literature | ||
| 17. | ALA1816105 | A | Growth inhibition of Agrobacterium tumefaciens WCF (pCF372) at 10 uM after 4 to 16 hrs | Agrobacterium tumefaciens | 21 | organism-based format | Scientific Literature | ||
| 18. | ALA1827923 | F | Agonist activity at Pseudomonas aeruginosa LasR cognate receptor expressed in Escherichia coli harboring pKDT17 assessed as activation of lasB expression by LacZ reporter gene assay | Pseudomonas aeruginosa | 8 | assay format | Scientific Literature | ||
| 19. | ALA3239380 | F | Antimicrobial activity against Staphylococcus aureus RN6390B assessed as growth inhibition up to 100 uM after 18 hrs by spectrophotometry | Staphylococcus aureus | 30 | organism-based format | Scientific Literature | ||
| 20. | ALA3239381 | B | Inhibition of AIP-1-induced AgrC-I activation in Staphylococcus aureus RN6390B up to 100 uM after 55 mins by beta-lactamase reporter assay | Staphylococcus aureus | 25 | assay format | Scientific Literature |
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