# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1827031 | B | Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in HEK293 cells after 60 mins | Homo sapiens | 23 | ALA1821619 | cell-based format | Scientific Literature | |
2. | ALA1827032 | B | Displacement of [125I]Iodoproxyfan from mouse brain cortex histamine H3 receptor after 60 mins | Mus musculus | 10 | ALA1821619 | tissue-based format | Scientific Literature | |
3. | ALA1827034 | A | Inhibition of CYP3A4 | 5 | ALA1821619 | single protein format | Scientific Literature | ||
4. | ALA1827182 | A | Inhibition of CYP2D6 | 5 | ALA1821619 | single protein format | Scientific Literature | ||
5. | ALA1827184 | A | Inhibition of CYP2C9 | 8 | ALA1821619 | single protein format | Scientific Literature | ||
6. | ALA1827186 | B | Inhibition of human ERG expressed in HEK293 cells at 10 uM by patch clamp assay | Homo sapiens | 6 | ALA1821619 | cell-based format | Scientific Literature | |
7. | ALA1827187 | F | Inverse agonist activity at histamine H3 receptor in po dosed Swiss mouse assessed as brain N-tele-methylhistamine level measured after 90 mins by enzyme immunoassay | Mus musculus | 6 | ALA1821619 | organism-based format | Scientific Literature | |
8. | ALA1827188 | A | Metabolic stability in human liver microsomes at 100 nM upto 250 mins by LC-MS/MS | Homo sapiens | 1 | ALA1821619 | microsome format | Scientific Literature | |
9. | ALA1827189 | A | Metabolic stability in mouse liver microsomes at 100 nM upto 250 mins by LC-MS/MS | Mus musculus | 1 | ALA1821619 | microsome format | Scientific Literature | |
10. | ALA1827190 | A | AUC (0 to 8 hrs) in Swiss mouse plasma at 10 mg/kg, po by LC-MS/MS | Mus musculus | 1 | ALA1821619 | organism-based format | Scientific Literature | |
11. | ALA1827191 | A | AUC (0 to 8 hrs) in Swiss mouse brain at 10 mg/kg, po by LC-MS/MS | Mus musculus | 1 | ALA1821619 | organism-based format | Scientific Literature | |
12. | ALA1827196 | A | Ratio of AUC (0 to 8 hrs) in Swiss mouse brain to AUC (0 to 8 hrs) in Swiss mouse plasma at 10 mg/kg, po by LC-MS/MS | Mus musculus | 1 | ALA1821619 | organism-based format | Scientific Literature | |
13. | ALA2378542 | A | Ratio of drug level in brain to plasma in Swiss mouse at 10 mg/kg, po | Mus musculus | 1 | ALA2375312 | organism-based format | Scientific Literature | |
14. | ALA2378547 | F | Inverse agonist activity at histamine H3 receptor in po dosed Swiss mouse assessed as release of N-tele-methylhistamine in brain after 90 mins by enzyme-immunoassay | Mus musculus | 2 | ALA2375312 | organism-based format | Scientific Literature | |
15. | ALA2378549 | A | Half life in Swiss mouse at 10 mg/kg, po | Mus musculus | 1 | ALA2375312 | organism-based format | Scientific Literature | |
16. | ALA2378552 | A | Half life in Swiss mouse brain | Mus musculus | 2 | ALA2375312 | tissue-based format | Scientific Literature | |
17. | ALA2378553 | A | Cmax in Swiss mouse brain | Mus musculus | 2 | ALA2375312 | tissue-based format | Scientific Literature | |
18. | ALA2378554 | A | Half life in Swiss mouse plasma | Mus musculus | 2 | ALA2375312 | cell-free format | Scientific Literature | |
19. | ALA2378555 | A | Tmax in Swiss mouse brain | Mus musculus | 2 | ALA2375312 | tissue-based format | Scientific Literature | |
20. | ALA2378556 | A | Cmax in Swiss mouse plasma | Mus musculus | 2 | ALA2375312 | cell-free format | Scientific Literature |