| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1827031 | B | Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in HEK293 cells after 60 mins | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 2. | ALA1827032 | B | Displacement of [125I]Iodoproxyfan from mouse brain cortex histamine H3 receptor after 60 mins | Mus musculus | 10 | tissue-based format | Scientific Literature | ||
| 3. | ALA1827034 | A | Inhibition of CYP3A4 | 5 | single protein format | Scientific Literature | |||
| 4. | ALA1827182 | A | Inhibition of CYP2D6 | 5 | single protein format | Scientific Literature | |||
| 5. | ALA1827184 | A | Inhibition of CYP2C9 | 8 | single protein format | Scientific Literature | |||
| 6. | ALA1827186 | B | Inhibition of human ERG expressed in HEK293 cells at 10 uM by patch clamp assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 7. | ALA1827187 | F | Inverse agonist activity at histamine H3 receptor in po dosed Swiss mouse assessed as brain N-tele-methylhistamine level measured after 90 mins by enzyme immunoassay | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 8. | ALA1827188 | A | Metabolic stability in human liver microsomes at 100 nM upto 250 mins by LC-MS/MS | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 9. | ALA1827189 | A | Metabolic stability in mouse liver microsomes at 100 nM upto 250 mins by LC-MS/MS | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 10. | ALA1827190 | A | AUC (0 to 8 hrs) in Swiss mouse plasma at 10 mg/kg, po by LC-MS/MS | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA1827191 | A | AUC (0 to 8 hrs) in Swiss mouse brain at 10 mg/kg, po by LC-MS/MS | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA1827196 | A | Ratio of AUC (0 to 8 hrs) in Swiss mouse brain to AUC (0 to 8 hrs) in Swiss mouse plasma at 10 mg/kg, po by LC-MS/MS | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA2378542 | A | Ratio of drug level in brain to plasma in Swiss mouse at 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA2378547 | F | Inverse agonist activity at histamine H3 receptor in po dosed Swiss mouse assessed as release of N-tele-methylhistamine in brain after 90 mins by enzyme-immunoassay | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA2378549 | A | Half life in Swiss mouse at 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA2378552 | A | Half life in Swiss mouse brain | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 17. | ALA2378553 | A | Cmax in Swiss mouse brain | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 18. | ALA2378554 | A | Half life in Swiss mouse plasma | Mus musculus | 2 | cell-free format | Scientific Literature | ||
| 19. | ALA2378555 | A | Tmax in Swiss mouse brain | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 20. | ALA2378556 | A | Cmax in Swiss mouse plasma | Mus musculus | 2 | cell-free format | Scientific Literature |
The page will load shortly, Thanks for your patience!