| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1833625 | B | Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting | Homo sapiens | 32 | ALA1828587 | cell-based format | Scientific Literature | |
| 2. | ALA1833626 | F | Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP enzyme immunoassay | Homo sapiens | 32 | ALA1828587 | cell-based format | Scientific Literature | |
| 3. | ALA1833627 | F | Antagonist activity at rat CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP enzyme immunoassay | Rattus norvegicus | 1 | ALA1828587 | cell-based format | Scientific Literature | |
| 4. | ALA1833628 | F | Anxiolytic activity against swim-stress-induced anxiety like behavior in Sprague-Dawley rat assessed as increase in spent time in open arms at 10 mg/kg, po administered 1 hr before stress-challenge by elevated plus-maze test | Rattus norvegicus | 1 | ALA1828587 | organism-based format | Scientific Literature | |
| 5. | ALA1833629 | A | AUC (0 to infinity) in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA1828587 | organism-based format | Scientific Literature | |
| 6. | ALA1833630 | A | AUC (0 to infinity) in rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA1828587 | organism-based format | Scientific Literature | |
| 7. | ALA1833631 | A | Tmax in rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA1828587 | organism-based format | Scientific Literature | |
| 8. | ALA1833632 | A | Cmax in rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA1828587 | organism-based format | Scientific Literature | |
| 9. | ALA1833633 | A | Total clearance in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA1828587 | organism-based format | Scientific Literature | |
| 10. | ALA1833634 | A | Half life in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA1828587 | organism-based format | Scientific Literature | |
| 11. | ALA1833635 | A | Half life in rat at 10 mg/kg, po | Rattus norvegicus | 1 | ALA1828587 | organism-based format | Scientific Literature | |
| 12. | ALA1833636 | A | Volume of distribution at steady state in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA1828587 | organism-based format | Scientific Literature | |
| 13. | ALA1833637 | A | Oral bioavailability in rat at 10 mg/kg | Rattus norvegicus | 1 | ALA1828587 | organism-based format | Scientific Literature | |
| 14. | ALA1833638 | A | Ratio of drug level in brain to plasma in rat at 10 mg/kg, po after 1 hr | Rattus norvegicus | 1 | ALA1828587 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!