# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1838728 | T | Induction of mutagenicity in Salmonella Typhimurium TA98 at 1 mg/mL after 48 hrs by Ames assay in presence of rat liver S9 metabolic activation system | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | ALA1833788 | organism-based format | Scientific Literature | |
2. | ALA1838729 | T | Induction of mutagenicity in Salmonella Typhimurium TA98 at 1 mg/mL after 48 hrs by Ames assay in absence of rat liver S9 metabolic activation system | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | ALA1833788 | organism-based format | Scientific Literature | |
3. | ALA1839476 | B | Inhibition of human recombinant MMP2 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry | Homo sapiens | 8 | ALA1833788 | single protein format | Scientific Literature | |
4. | ALA1839477 | B | Inhibition of human recombinant MMP9 catalytic domain assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry | Homo sapiens | 8 | ALA1833788 | single protein format | Scientific Literature | |
5. | ALA1839478 | A | Half life in mouse liver microsomes at 100 uM by reversed-phase HPLC/UV analysis | Mus musculus | 2 | ALA1833788 | microsome format | Scientific Literature | |
6. | ALA1839480 | A | Half life in rat liver microsomes at 100 uM by reversed-phase HPLC/UV analysis | Rattus norvegicus | 2 | ALA1833788 | microsome format | Scientific Literature | |
7. | ALA1839481 | A | Half life in human liver microsomes at 100 uM by reversed-phase HPLC/UV analysis | Homo sapiens | 2 | ALA1833788 | microsome format | Scientific Literature | |
8. | ALA1839482 | A | Apparent intrinsic clearance in mouse liver microsomes | Mus musculus | 2 | ALA1833788 | microsome format | Scientific Literature | |
9. | ALA1839483 | A | Apparent intrinsic clearance in rat liver microsomes | Rattus norvegicus | 2 | ALA1833788 | microsome format | Scientific Literature | |
10. | ALA1839484 | A | Apparent intrinsic clearance in human liver microsomes | Homo sapiens | 2 | ALA1833788 | microsome format | Scientific Literature | |
11. | ALA1839488 | A | Prodrug conversion in rat liver microsomes assessed as release of 2-amino-5-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenol after 30 mins by HPLC/MS analysis | Rattus norvegicus | 1 | ALA1833788 | microsome format | Scientific Literature | |
12. | ALA1839489 | A | Prodrug conversion in rat liver microsomes assessed as release of 4-(4-{[(1-oxidothiiran-2-yl)methyl]sulfonyl}phenoxy)aniline after 30 mins by HPLC/MS analysis | Rattus norvegicus | 1 | ALA1833788 | microsome format | Scientific Literature | |
13. | ALA1839741 | T | Induction of mutagenicity in Salmonella Typhimurium TA7001 to TA7006 at 1 mg/mL after 48 hrs by Ames assay in presence of rat liver S9 metabolic activation system | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | ALA1833788 | organism-based format | Scientific Literature | |
14. | ALA1839742 | T | Induction of mutagenicity in Salmonella Typhimurium TA7001 to TA7006 at 1 mg/mL after 48 hrs by Ames assay in absence of rat liver S9 metabolic activation system | Salmonella enterica subsp. enterica serovar Typhimurium | 2 | ALA1833788 | organism-based format | Scientific Literature | |
15. | ALA1839743 | B | Inhibition of human recombinant MMP14 catalytic domain assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry | Homo sapiens | 3 | ALA1833788 | single protein format | Scientific Literature | |
16. | ALA1839749 | B | Inhibition of human recombinant MMP7 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 at 250 uM by fluorescence spectrofluorometry | Homo sapiens | 1 | ALA1833788 | single protein format | Scientific Literature | |
17. | ALA1839751 | B | Inhibition of human recombinant MMP1 catalytic domain assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 at 250 uM by fluorescence spectrofluorometry | Homo sapiens | 1 | ALA1833788 | single protein format | Scientific Literature | |
18. | ALA1839753 | B | Inhibition of human recombinant MMP3 catalytic domain assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry | Homo sapiens | 2 | ALA1833788 | single protein format | Scientific Literature | |
19. | ALA2445513 | A | Elimination half life in rat liver S9 fraction at 10 uM by reversed-phase UPLC/ESI-MRM analysis | Rattus norvegicus | 1 | ALA2440018 | subcellular format | Scientific Literature | |
20. | ALA2445514 | A | Primary phase half life in rat liver S9 fraction at 10 uM by reversed-phase UPLC/ESI-MRM analysis | Rattus norvegicus | 1 | ALA2440018 | subcellular format | Scientific Literature |