| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1837741 | B | Inhibition human recombinant cSRC using KVEKIGEGTYGVVYK peptide substrate in presence of [gamma-32P]-ATP | Homo sapiens | 22 | single protein format | Scientific Literature | ||
| 2. | ALA1837743 | B | Inhibition human recombinant Abl using Abtide peptide substrate in presence of [gamma-32P]-ATP | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 3. | ALA1837749 | F | Antiproliferative activity against human SH-SY5Y cells assessed as cell viability at 0.01 to 10 uM by XTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA1837750 | F | Antiproliferative activity against human SH-SY5Y cells assessed as cell viability after 72 hrs by XTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 5. | ALA1837751 | A | Antiproliferative activity against human HS27 cells assessed as retardation in proliferation rate at 10 uM after 72 hrs by XTT assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA1837752 | A | Permeability of the compound at pH 7.4 after 5 hrs using porcine polar brain lipid by PAMPA-BBB assay | 3 | assay format | Scientific Literature | |||
| 7. | ALA1837753 | P | Aqueous solubility of the compound after 24 to 36 hrs by LC-MS-MS assay | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA1837754 | A | Metabolic stability in human liver microsomes at 50 uM at pH 7.4 using NADPH by LC-UV-MS method | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 9. | ALA2411059 | F | Cytotoxicity against mouse 32D cells expressing BCR/ABL T315I mutant after 48 hrs by trypan blue dye exclusion assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA2411060 | B | Inhibition of c-SRC phosphorylation at Y416 in mouse 32D cells expressing BCR/ABL fusion protein p210 at 1 uM by Western blotting analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA2411061 | B | Inhibition of BCR/ABL (unknown origin) phosphorylation at Y412 transfected in mouse 32D cells at 1 uM by Western blotting analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA2411063 | B | Inhibition of recombinant wild type c-ABL (unknown origin) after 5 mins by scintillation counting analysis in presence of [gamma32P]ATP | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA2411065 | B | Inhibition of recombinant c-SRC (unknown origin) after 5 mins by scintillation counting analysis in presence of [gamma32P]ATP | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 14. | ALA2411066 | A | Apparent permeability of the compound after 5 hrs by PAMPA | 4 | assay format | Scientific Literature | |||
| 15. | ALA2411067 | A | Apparent permeability of the compound assessed as membrane retention after 5 hrs by PAMPA | 3 | assay format | Scientific Literature | |||
| 16. | ALA2411068 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 50 uM after 60 mins by UV/LC/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 17. | ALA2411069 | A | Half life in human plasma at 1 mM by HPLC analysis | Homo sapiens | 4 | cell-free format | Scientific Literature | ||
| 18. | ALA2411070 | P | Half life in phosphate buffer at 500 uM at pH 7.4 by HPLC analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 19. | ALA2411071 | P | Half life in methanol at 500 uM by HPLC analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 20. | ALA2411072 | P | Thermodynamic solubility of the compound in water at 1 mg after 24 hrs by UV/LC-MS analysis | 3 | small-molecule physicochemical format | Scientific Literature |
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