# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3607815 | Functional | Antitrypanosomal activity against bloodstream forms of Trypanosoma brucei rhodesiense STIB 900 after 72 hrs by alamar blue assay | Trypanosoma brucei rhodesiense | 29 | ALA3603776 | organism-based format | Scientific Literature | |
2. | ALA3607816 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for bloodstream forms of Trypanosoma brucei rhodesiense STIB 900 | 29 | ALA3603776 | cell-based format | Scientific Literature | ||
3. | ALA3606216 | ADME | Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay | Rattus norvegicus | 33 | ALA3603776 | cell-based format | Scientific Literature | |
4. | ALA3606374 | Toxicity | Toxicity in late-stage human african trypanosomiasis patient assessed as mortality rate following 10-day schedule | Homo sapiens | 1 | ALA3603826 | organism-based format | Scientific Literature | |
5. | ALA3614237 | Functional | Antiparasitic activity against trypomastigote stage of Trypanosoma brucei rhodesiense STIB 900 assessed as parasite growth inhibition after 72 hrs by Alamar blue assay | Trypanosoma brucei rhodesiense | 14 | ALA3611981 | organism-based format | Scientific Literature | |
6. | ALA3636811 | Functional | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB900 assessed as growth inhibition after 70 hrs by resazurin dye-based fluorometric analysis | Trypanosoma brucei rhodesiense | 14 | ALA3632462 | organism-based format | Scientific Literature | |
7. | ALA3637523 | Functional | Antitrypanosomal activity against bloodstream trypomastigote forms of Trypanosoma brucei rhodesiense STIB 900 assessed as inhibition of growth | Trypanosoma brucei rhodesiense | 19 | ALA3632593 | organism-based format | Scientific Literature | |
8. | ALA3755945 | Functional | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 after 72 hrs by alamar blue assay | Trypanosoma brucei rhodesiense | 13 | ALA3751823 | organism-based format | Scientific Literature | |
9. | ALA3804439 | Functional | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 measured after 70 hrs by alamar blue staining based fluorescence analysis | Trypanosoma brucei rhodesiense | 88 | ALA3797193 | organism-based format | Scientific Literature | |
10. | ALA3804440 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900 | 85 | ALA3797193 | cell-based format | Scientific Literature | ||
11. | ALA3804441 | ADME | Cytotoxicity against rat L6 cells measured after 70 hrs by alamar blue staining based fluorescence analysis | Rattus norvegicus | 86 | ALA3797193 | cell-based format | Scientific Literature | |
12. | ALA3806442 | Functional | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB 900 trypomastigotes assessed as inhibition of parasite growth after 72 hrs by Alamar blue assay | Trypanosoma brucei rhodesiense | 12 | ALA3804781 | organism-based format | Scientific Literature | |
13. | ALA3815295 | Functional | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream forms after 72 hrs by Alamar blue assay | Trypanosoma brucei rhodesiense | 21 | ALA3813611 | organism-based format | Scientific Literature | |
14. | ALA3815296 | ADME | Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay | Rattus norvegicus | 24 | ALA3813611 | cell-based format | Scientific Literature | |
15. | ALA3815298 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB 900 bloodstream forms | 21 | ALA3813611 | cell-based format | Scientific Literature | ||
16. | ALA3829072 | Functional | Antiparasitic activity against bloodstream forms of Trypanosoma brucei rhodesiense STIB 900 assessed as growth inhibition after 72 hrs by resazurin assay | Trypanosoma brucei rhodesiense | 13 | ALA3826916 | organism-based format | Scientific Literature | |
17. | ALA711743 | Functional | In Vitro cytotoxicity on MRC-5 cells | Homo sapiens | 3 | ALA1133105 | cell-based format | Scientific Literature | |
18. | ALA711744 | Functional | Tested for cytotoxicity towards human MRC-5 cells | Homo sapiens | 20 | ALA1136044 | cell-based format | Scientific Literature | |
19. | ALA852824 | Functional | Ratio of cytotoxicity against L6 cells to that of antitrypanosomal activity against Trypanosoma brucei rhodesiense | 37 | ALA1149160 | cell-based format | Scientific Literature | ||
20. | ALA838592 | Functional | In vivo antitrypanosomal activity at a dose of 4*8 mg/kg, i.p., in mice infected with Trypanosoma brucei brucei STIB 795 strain, measured as survival days (control 7 days) | Mus musculus | 1 | ALA1141164 | organism-based format | Scientific Literature |