The compound was tested for in vivo activity against a rodent model of Trypanosoma brucei at the specified dose: 5 mg/kg, ip no. of days dosing = 1; All servived
In vivo antitrypanosomal activity at a dose of 4*8 mg/kg, i.p., in mice infected with Trypanosoma brucei brucei STIB 795 strain, measured as survival days (control 7 days)
In vivo antitrypanosomal activity at a dose of 4*8 mg/kg, i.p., in mice infected with Trypanosoma brucei rhodesiense STIB 900 strain, measured as survival days (control 7 days); ND is not determined
In vivo antitrypanosomal activity at a dose of 4*8 mg/kg, i.p., in mice infected with Trypanosoma brucei rhodesiense STIB 900 strain, measured as cured/infected; 4/4
In vitro inhibitory concentration against P2 aminopurine transporter of Trypanosoma brucei brucei 427 adenosine (0.5 uM) uptake in presence of 1 mM inosine
Inhibitory concentration in vitro against intracellular amastigotes of Leishmania donovani in rat skeletal myoblasts incubated for 96 hr at 27 degree C
In vitro inhibitory concentration against intracellular amastigotes of Trypanosoma cruzi in rat skeletal myoblasts incubated for 37 degree C for 4 days
In vivo antitrypanosomal activity at a dose of 4*1 mg/kg, i.p., in mice infected with Trypanosoma brucei brucei STIB 795 strain, measured as survival days (control 7 days)