# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA663133 | B | Binding energy to Streptococcus faecium dihydrofolate reductase | Enterococcus faecium | 68 | ALA1122106 | single protein format | Scientific Literature | |
2. | ALA663137 | B | Binding energy against Streptococcus faecium dihydrofolate reductase | Enterococcus faecium | 68 | ALA1121631 | single protein format | Scientific Literature | |
3. | ALA666235 | B | The concentration required to inhibit dihydrofolate reductase in rat liver | 107 | ALA1122689 | tissue-based format | Scientific Literature | ||
4. | ALA666238 | B | Concentration required for inhibition of rat liver dihydrofolate reductase (DHFR) | 103 | ALA1122259 | assay format | Scientific Literature | ||
5. | ALA3257257 | F | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in sc dosed mouse assessed as minimum curative dose | Plasmodium berghei | 36 | ALA3244272 | organism-based format | Scientific Literature | |
6. | ALA3257263 | F | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 20 mg/kg, sc single dose after 72 hrs of infection | Plasmodium berghei | 32 | ALA3244272 | organism-based format | Scientific Literature | |
7. | ALA3257264 | F | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 10 mg/kg, sc single dose after 72 hrs of infection | Plasmodium berghei | 27 | ALA3244272 | organism-based format | Scientific Literature | |
8. | ALA3257265 | F | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 5 mg/kg, sc single dose after 72 hrs of infection | Plasmodium berghei | 17 | ALA3244272 | organism-based format | Scientific Literature | |
9. | ALA3257266 | F | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 2.5 mg/kg, sc single dose after 72 hrs of infection | Plasmodium berghei | 18 | ALA3244272 | organism-based format | Scientific Literature | |
10. | ALA3257267 | F | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 1.25 mg/kg, sc single dose after 72 hrs of infection | Plasmodium berghei | 15 | ALA3244272 | organism-based format | Scientific Literature | |
11. | ALA3259100 | F | Antimalarial activity against sporozoite-induced Plasmodium gallinaceum infected in chick assessed as change in cured at 120 mg/kg, sc single dose | Plasmodium gallinaceum | 2 | ALA3244272 | organism-based format | Scientific Literature | |
12. | ALA3254073 | F | Antibacterial activity against Streptococcus faecalis MGH-2 assessed as growth inhibition | Enterococcus faecalis | 29 | ALA3244272 | organism-based format | Scientific Literature | |
13. | ALA3254074 | F | Antibacterial activity against Staphylococcus aureus UC-76 assessed as growth inhibition | Staphylococcus aureus | 29 | ALA3244272 | organism-based format | Scientific Literature | |
14. | ALA3254075 | F | Antibacterial activity against Staphylococcus aureus S18713 assessed as growth inhibition | Staphylococcus aureus | 29 | ALA3244272 | organism-based format | Scientific Literature | |
15. | ALA3254076 | F | Antibacterial activity against Pseudomonas aeruginosa 28 assessed as growth inhibition | Pseudomonas aeruginosa | 29 | ALA3244272 | organism-based format | Scientific Literature | |
16. | ALA3254077 | F | Antibacterial activity against Escherichia coli Vogel assessed as growth inhibition | Escherichia coli | 29 | ALA3244272 | organism-based format | Scientific Literature | |
17. | ALA3254078 | F | Antibacterial activity against Shigella sonnei C-10 assessed as growth inhibition | Shigella sonnei | 29 | ALA3244272 | organism-based format | Scientific Literature | |
18. | ALA3254079 | F | Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition | Mycobacterium tuberculosis | 29 | ALA3244272 | organism-based format | Scientific Literature | |
19. | ALA3280748 | B | Inhibition of liver dihydrofolate reductase (unknown origin) | Homo sapiens | 104 | ALA3272031 | assay format | Scientific Literature | |
20. | ALA3280522 | B | Inhibition of Streptococcus faecium dihydrofolate reductase using dihydrofolate as substrate | Enterococcus faecium | 66 | ALA3272349 | single protein format | Scientific Literature |