| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA620951 | A | Oral bioavailability in cynomolgus monkeys for the compound was determined; Acceptable | Macaca fascicularis | 1 | ALA1134995 | organism-based format | Scientific Literature | |
| 2. | ALA618983 | A | Percent of the parent compound remaining after 20 mins incubation with human liver microsomes | Homo sapiens | 9 | ALA1133934 | microsome format | Scientific Literature | |
| 3. | ALA623454 | A | Percent parent compound remaining after 20 min incubation with human liver microsomes | Homo sapiens | 18 | ALA1134995 | microsome format | Scientific Literature | |
| 4. | ALA618582 | A | Pharmacokinetic property at the dose of 10 mg/kg (20% HPbetaCD) concentration in cynomolgus monkeys (0 to 24 hr) p.o. | Cercopithecidae | 1 | ALA1133934 | organism-based format | Scientific Literature | |
| 5. | ALA621609 | A | Area under curve was determined | 2 | ALA1134995 | assay format | Scientific Literature | ||
| 6. | ALA626550 | A | Pharmacokinetic property at the dose of 10 mg/kg (20% HPbetaCD) concentration in rat (0 to 6 hr) p.o. | Rattus norvegicus | 4 | ALA1133934 | organism-based format | Scientific Literature | |
| 7. | ALA623068 | A | Oral bioavailability in rats was determined; High | Rattus norvegicus | 1 | ALA1134995 | organism-based format | Scientific Literature | |
| 8. | ALA883126 | P | Calculated partition coefficient (ClogP) for the compound | 2 | ALA1134995 | small-molecule physicochemical format | Scientific Literature | ||
| 9. | ALA625052 | P | Calculated partition coefficient (clogP) | 5 | ALA1133934 | small-molecule physicochemical format | Scientific Literature | ||
| 10. | ALA638329 | A | Area under curve (high throughput single measurement) after peroral administration (10 mg/kg, 0-6 hr) in rat was determined | Rattus norvegicus | 2 | ALA1135669 | organism-based format | Scientific Literature | |
| 11. | ALA646685 | P | Calculated partition coefficient (clogP) | 9 | ALA1135669 | small-molecule physicochemical format | Scientific Literature | ||
| 12. | ALA745725 | B | Selectivity ratio of M1 muscarinic receptor to that of M2 muscarinic receptor | 7 | ALA1133934 | single protein format | Scientific Literature | ||
| 13. | ALA745726 | B | Selectivity ratio of M3 muscarinic receptor to that of M2 muscarinic receptor | 7 | ALA1133934 | single protein format | Scientific Literature | ||
| 14. | ALA745693 | B | Selectivity as the ratio of Ki of Muscarinic acetylcholine receptor M1 to that of Muscarinic acetylcholine receptor M2 | 1 | ALA1135669 | single protein format | Scientific Literature | ||
| 15. | ALA745193 | F | Antagonistic activity against muscarinic acetylcholine receptor M2 | 7 | ALA1133934 | assay format | Scientific Literature | ||
| 16. | ALA748895 | B | Binding affinity for human Muscarinic acetylcholine receptor M2 | Homo sapiens | 9 | ALA1135669 | single protein format | Scientific Literature | |
| 17. | ALA772851 | F | ACh released compared with baseline (100%) in rat striatum after peroral administration (0-2 h,10 mg/kg, 20% HPbetaCD) using microdialysis assay | Rattus norvegicus | 5 | ALA1135669 | organism-based format | Scientific Literature | |
| 18. | ALA773475 | F | Efficacy was tested in a rat microdialysis assay where ACh release levels were measured | Rattus norvegicus | 3 | ALA1134995 | organism-based format | Scientific Literature | |
| 19. | ALA788181 | F | Percent of Acetylcholine (ACh) released above baseline in rat striatum at the dose of 10 mg/kg p.o. (0-2h) | Rattus norvegicus | 5 | ALA1133934 | organism-based format | Scientific Literature | |
| 20. | ALA793163 | F | Orally active dose in passive avoidance response (PAR) | Rattus norvegicus | 3 | ALA1135669 | organism-based format | Scientific Literature |
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