| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3540640 | ADME | Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 9 | ALA3526100 | assay format | Scientific Literature | |
| 2. | ALA3540641 | ADME | Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 9 | ALA3526100 | assay format | Scientific Literature | |
| 3. | ALA3540642 | ADME | Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by refined CYP450 IC50 shift assay in presence of NADPH | Homo sapiens | 9 | ALA3526100 | assay format | Scientific Literature | |
| 4. | ALA3540643 | ADME | Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by refined CYP450 IC50 shift assay | Homo sapiens | 9 | ALA3526100 | assay format | Scientific Literature | |
| 5. | ALA3537878 | ADME | Apparent intrinsic clearance in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by conventional assay | Rattus norvegicus | 8 | ALA3525918 | cell-based format | Scientific Literature | |
| 6. | ALA3537879 | ADME | Drug metabolism in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by conventional assay | Rattus norvegicus | 4 | ALA3525918 | cell-based format | Scientific Literature | |
| 7. | ALA3537880 | ADME | Apparent intrinsic clearance in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by media-loss method | Rattus norvegicus | 8 | ALA3525918 | cell-based format | Scientific Literature | |
| 8. | ALA3537881 | ADME | Drug metabolism in Sprague-Dawley rat hepatocytes assessed per 10'6 cells at 0.1 to 10 uM up to 90 mins by media-loss method | Rattus norvegicus | 4 | ALA3525918 | cell-based format | Scientific Literature | |
| 9. | ALA3541093 | ADME | Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method | Homo sapiens | 69 | ALA3526101 | single protein format | Scientific Literature | |
| 10. | ALA3534882 | ADME | Time dependent inhibition of CYP1A2 (unknown origin) at 100 uM by LC/MS system | Homo sapiens | 42 | ALA3526118 | single protein format | Scientific Literature | |
| 11. | ALA3534883 | ADME | Time dependent inhibition of CYP2B6 (unknown origin) at 100 uM by LC/MS system | Homo sapiens | 34 | ALA3526118 | single protein format | Scientific Literature | |
| 12. | ALA3534884 | ADME | Time dependent inhibition of CYP2C9 (unknown origin) at 100 uM by LC/MS system | Homo sapiens | 35 | ALA3526118 | single protein format | Scientific Literature | |
| 13. | ALA3534885 | ADME | Time dependent inhibition of CYP2C19 in human liver microsomes at 100 uM by LC/MS system | Homo sapiens | 38 | ALA3526118 | assay format | Scientific Literature | |
| 14. | ALA3534886 | ADME | Time dependent inhibition of CYP2D6 (unknown origin) at 100 uM by LC/MS system | Homo sapiens | 37 | ALA3526118 | single protein format | Scientific Literature | |
| 15. | ALA3534887 | ADME | Time dependent inhibition of CYP3A4 (unknown origin) at 100 uM by LC/MS system | Homo sapiens | 35 | ALA3526118 | single protein format | Scientific Literature | |
| 16. | ALA3534888 | ADME | Covalent binding in human liver microsomes measured per mg of protein using radiolabelled compound at 10 uM after 1 hr incubation by liquid scintillation counting | Homo sapiens | 42 | ALA3526118 | assay format | Scientific Literature | |
| 17. | ALA3534889 | ADME | Metabolic activation in human liver microsomes assessed as [3H]GSH adduct formation rate measured per mg of protein at 100 uM by [3H]GSH trapping assay | Homo sapiens | 42 | ALA3526118 | assay format | Scientific Literature | |
| 18. | ALA3534890 | ADME | Time dependent inhibition of CYP2C8 (unknown origin) at 100 uM by LC/MS system | Homo sapiens | 34 | ALA3526118 | single protein format | Scientific Literature | |
| 19. | ALA3534905 | ADME | Intrinsic clearance for reactive metabolites formation per mg of protein in human liver microsomes based on [3H]GSH adduct formation rate at 100 uM by [3H]GSH trapping assay | Homo sapiens | 42 | ALA3526118 | assay format | Scientific Literature | |
| 20. | ALA3534906 | ADME | Intrinsic clearance for reactive metabolites formation per mg of protein based on cytochrome P450 (unknown origin) inactivation rate by TDI assay | Homo sapiens | 42 | ALA3526118 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!