Assay

#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA1912841	Binding	Binding affinity to histidine-tagged human recombinant 14-3-3sigma by transferred NOESY analysis	Homo sapiens	1	ALA1909530	single protein format	Scientific Literature
2.	ALA1912842	Binding	Inhibition of 14-3-3sigma binding domain in human Ba/F3 cells expressing imatibib-sensitive wild type Bcr-Abl construct assessed as inhibition of 14-3-3sigma-c-Abl interaction	Homo sapiens	3	ALA1909530	cell-based format	Scientific Literature
3.	ALA1912843	Binding	Inhibition of 14-3-3sigma binding domain in human Ba/F3 cells expressing imatibib-resistant Bcr-Abl T315I mutant construct assessed as inhibition of 14-3-3sigma-c-Abl interaction	Homo sapiens	2	ALA1909530	cell-based format	Scientific Literature
4.	ALA1912844	Binding	Inhibition of 14-3-3sigma in human Ba/F3 cells expressing imatinib-sensitive wild type Bcr-Abl construct assessed as release of full-length c-Abl from cytoplasmic complex with 14-3-3sigma at 5 uM after 24 hrs by immunoprecipitation/immunoblot technique	Homo sapiens	1	ALA1909530	cell-based format	Scientific Literature
5.	ALA1912846	Binding	Inhibition of 14-3-3sigma in human Ba/F3 cells expressing imatinib-sensitive wild type Bcr-Abl construct assessed as nuclear import of full-length c-Abl at 5 uM after 24 hrs by immunoprecipitation/immunoblot technique	Homo sapiens	1	ALA1909530	cell-based format	Scientific Literature
6.	ALA1912848	Binding	Inhibition of 14-3-3sigma in human Ba/F3 cells expressing imatinib-sensitive wild type Bcr-Abl construct assessed as relocation of full-length c-Abl to mitochondrial membranes at 5 uM after 24 hrs by immunoprecipitation/immunoblot technique	Homo sapiens	1	ALA1909530	cell-based format	Scientific Literature
7.	ALA1912849	Binding	Inhibition of 14-3-3sigma in human Ba/F3 cells expressing imatinib-sensitive wild type Bcr-Abl construct assessed as cleaved c-Abl at mitochondrial membranes at 5 uM after 24 hrs by immunoprecipitation/immunoblot technique	Homo sapiens	1	ALA1909530	cell-based format	Scientific Literature