# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA663133 | B | Binding energy to Streptococcus faecium dihydrofolate reductase | Enterococcus faecium | 68 | single protein format | Scientific Literature | ||
2. | ALA663137 | B | Binding energy against Streptococcus faecium dihydrofolate reductase | Enterococcus faecium | 68 | single protein format | Scientific Literature | ||
3. | ALA666235 | B | The concentration required to inhibit dihydrofolate reductase in rat liver | 107 | tissue-based format | Scientific Literature | |||
4. | ALA666236 | B | Inhibitory activity against dihydrofolate reductase of rat liver | 39 | assay format | Scientific Literature | |||
5. | ALA666238 | B | Concentration required for inhibition of rat liver dihydrofolate reductase (DHFR) | 103 | assay format | Scientific Literature | |||
6. | ALA3257257 | F | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in sc dosed mouse assessed as minimum curative dose | Plasmodium berghei | 36 | organism-based format | Scientific Literature | ||
7. | ALA3257264 | F | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 10 mg/kg, sc single dose after 72 hrs of infection | Plasmodium berghei | 27 | organism-based format | Scientific Literature | ||
8. | ALA3257265 | F | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 5 mg/kg, sc single dose after 72 hrs of infection | Plasmodium berghei | 17 | organism-based format | Scientific Literature | ||
9. | ALA3257266 | F | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 2.5 mg/kg, sc single dose after 72 hrs of infection | Plasmodium berghei | 18 | organism-based format | Scientific Literature | ||
10. | ALA3257267 | F | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in mouse assessed as change in mean survival time at 1.25 mg/kg, sc single dose after 72 hrs of infection | Plasmodium berghei | 15 | organism-based format | Scientific Literature | ||
11. | ALA3259106 | F | Antimalarial activity against Plasmodium gallinaceum infected in mouse assessed as quinine equivalent to dose required to suppress parasitemia by 75% compound treated through gavage for 3 days | Plasmodium gallinaceum | 8 | organism-based format | Scientific Literature | ||
12. | ALA3259108 | F | Antimalarial activity against Plasmodium gallinaceum parent strain infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days | Plasmodium gallinaceum | 8 | organism-based format | Scientific Literature | ||
13. | ALA3252246 | F | Antimalarial activity against chloroquine-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days | Plasmodium gallinaceum | 8 | organism-based format | Scientific Literature | ||
14. | ALA3252248 | F | Antimalarial activity against cycloguanil-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days | Plasmodium gallinaceum | 8 | organism-based format | Scientific Literature | ||
15. | ALA3252250 | F | Antimalarial activity against DDS-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days | Plasmodium gallinaceum | 8 | organism-based format | Scientific Literature | ||
16. | ALA3252252 | F | Antimalarial activity against chloroquine-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days relative to parent strain | Plasmodium gallinaceum | 8 | organism-based format | Scientific Literature | ||
17. | ALA3252254 | F | Antimalarial activity against cycloguanil-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days relative to parent strain | Plasmodium gallinaceum | 8 | organism-based format | Scientific Literature | ||
18. | ALA3253631 | F | Antimalarial activity against DDS-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days relative to parent strain | Plasmodium gallinaceum | 8 | organism-based format | Scientific Literature | ||
19. | ALA3253632 | F | Antimalarial activity against chloroquine-sensitive, pyrimethamine-resistant Plasmodium falciparum Malayan Camp CH/Q infected in Aotus monkey assessed as dose required to >50% cures compound treated for 7 days | Plasmodium falciparum | 9 | organism-based format | Scientific Literature | ||
20. | ALA3253633 | F | Antimalarial activity against chloroquine-resistant, pyrimethamine-sensitive Plasmodium falciparum Vietnam Oak Knoll in Aotus monkey assessed as dose required to >50% cures compound treated for 7 days | Plasmodium falciparum | 10 | organism-based format | Scientific Literature |