| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1921531 | B | Inhibition of human placental 17beta-HSD2 assessed as formation of [2,4,6,7-3H]-estrone using [2,4,6,7-3H]-estradiol as substrate after 20 mins by radio flow detector-based HPLC analysis in presence of NAD+ as cofactor | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 2. | ALA1921533 | B | Inhibition of human placental 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 mins by radio flow detector-based HPLC analysis in presence of NADH as cofactor | Homo sapiens | 26 | assay format | Scientific Literature | ||
| 3. | ALA1921535 | B | Selectivity ratio of IC50 for human placental 17beta-HSD1 to IC50 for human placental 17beta-HSD2 | Homo sapiens | 33 | assay format | Scientific Literature | ||
| 4. | ALA1921536 | B | Displacement of [3H]estradiol from human recombinant ERalpha assessed as relative binding affinity after 1 hr by liquid scintillation counting relative to estradiol | Homo sapiens | 34 | single protein format | Scientific Literature | ||
| 5. | ALA1921537 | B | Displacement of [3H]estradiol from human recombinant ERbeta assessed as relative binding affinity after 1 hr by liquid scintillation counting relative to estradiol | Homo sapiens | 34 | single protein format | Scientific Literature | ||
| 6. | ALA2328128 | B | Inhibition of 17beta-HSD2 in common marmoset placental microsomal fraction assessed as inhibition of [3H]E2 conversion to E1 at 1 uM by scintillation counting analysis | Callithrix jacchus | 5 | microsome format | Scientific Literature | ||
| 7. | ALA2328129 | B | Inhibition of 17beta-HSD2 in mouse liver microsomal fraction assessed as inhibition of [3H]E2 conversion to E1 at 1 uM by scintillation counting analysis | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 8. | ALA2328130 | B | Inhibition of 17beta-HSD2 in rat liver microsomal fraction assessed as inhibition of [3H]E2 conversion to E1 at 1 uM by scintillation counting analysis | Rattus norvegicus | 5 | microsome format | Scientific Literature | ||
| 9. | ALA2328131 | A | Cytotoxicity against human MDA-MB-231 cells at 50 uM after 3 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA2328132 | B | Selectivity ratio of IC50 for human recombinant 11beta-HSD1 to IC50 for human 17beta-HSD2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA2328133 | B | Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cell using [1,2,6,7-3H]cortisol as substrate at 2 uM after 10 mins by scintillation counting analysis | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 12. | ALA2328134 | B | Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cell using [1,2-3H]Cortisone as substrate after 10 mins by scintillation counting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA2328430 | B | Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cell using [1,2-3H]Cortisone as substrate at 2 uM after 10 mins by scintillation counting analysis | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 14. | ALA2328431 | B | Inhibition of human recombinant 17beta-HSD5 expressed in Escherichia coli using [1,2,6,7-3H]A-dione as substrate at 1 uM by scintillation counting analysis | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 15. | ALA2328432 | B | Inhibition of human recombinant 17beta-HSD4 SDR domain expressed in Escherichia coli using [6,7-3H]E2 as substrate at 1 uM by scintillation counting analysis | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 16. | ALA2328434 | B | Inhibition of 17beta-HSD2 in human MDA-MB-231 cells using [3H]E2 as substrate after 6 hrs by HPLC analysis | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 17. | ALA2328435 | B | Selectivity ratio of IC50 for 17beta-HSD1 in human placental microsomal fraction to IC50 for 17beta-HSD2 in human placental microsomal fraction | Homo sapiens | 19 | microsome format | Scientific Literature | ||
| 18. | ALA2328436 | B | Inhibition of 17beta-HSD1 in human placental cytosolic fraction using [3H]E1 as substrate assessed as formation of E2 by HPLC analysis | Homo sapiens | 19 | assay format | Scientific Literature | ||
| 19. | ALA2328437 | B | Inhibition of 17beta-HSD2 in human placental microsomal fraction using [3H]E2 as substrate assessed as formation of E1 by HPLC analysis | Homo sapiens | 19 | microsome format | Scientific Literature | ||
| 20. | ALA2328438 | B | Displacement of [3H]E2 from human recombinant ERbeta after 1 hr by scintillation counting analysis relative to E2 | Homo sapiens | 19 | single protein format | Scientific Literature |
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