# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1921590 | Binding | Inhibition of calf DNA polymerase alpha using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | Bos taurus | 21 | ALA1914406 | assay format | Scientific Literature | |
2. | ALA1921591 | Binding | Inhibition of histidine-tagged human DNA polymerase gamma using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | Homo sapiens | 22 | ALA1914406 | assay format | Scientific Literature | |
3. | ALA1921592 | Binding | Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | Homo sapiens | 21 | ALA1914406 | single protein format | Scientific Literature | |
4. | ALA1921593 | Binding | Inhibition of calf DNA polymerase alpha using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | Bos taurus | 21 | ALA1914406 | assay format | Scientific Literature | |
5. | ALA1921594 | Binding | Inhibition of histidine-tagged human DNA polymerase gamma using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | Homo sapiens | 22 | ALA1914406 | assay format | Scientific Literature | |
6. | ALA1921595 | Binding | Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | Homo sapiens | 21 | ALA1914406 | single protein format | Scientific Literature | |
7. | ALA1921596 | Binding | Inhibition of recombinant His-tagged human DNA polymerase lambda using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | Homo sapiens | 21 | ALA1914406 | single protein format | Scientific Literature | |
8. | ALA1919801 | Binding | Binding affinity to DNA assessed as thermal transition of DNA relative to control | 10 | ALA1914406 | nucleic acid format | Scientific Literature | ||
9. | ALA1919807 | ADME | Cytotoxicity against mouse RAW264.7 cells at 5 uM | Mus musculus | 21 | ALA1914406 | cell-based format | Scientific Literature | |
10. | ALA1919808 | ADME | Cytotoxicity against mouse RAW264.7 cells | Mus musculus | 21 | ALA1914406 | cell-based format | Scientific Literature | |
11. | ALA1919809 | Functional | Antiinflammatory activity in mouse assessed as inhibition of TPA-induced mouse ear edema at 500 ug/ear administered 30 mins before TPA challenge measured after 7 hrs relative to untreated control | Mus musculus | 21 | ALA1914406 | organism-based format | Scientific Literature | |
12. | ALA1920071 | Binding | Inhibition of recombinant His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | Homo sapiens | 21 | ALA1914406 | single protein format | Scientific Literature |