# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1931062 | Functional | Antagonist activity at human NOX1 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | Homo sapiens | 17 | ALA1926564 | cell-based format | Scientific Literature | |
2. | ALA1931063 | Functional | Antagonist activity at human NOX2 in human polymorphonuclear cell membrane assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | Homo sapiens | 17 | ALA1926564 | assay format | Scientific Literature | |
3. | ALA1931064 | Functional | Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | Homo sapiens | 17 | ALA1926564 | cell-based format | Scientific Literature | |
4. | ALA1931065 | Functional | Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assay | Homo sapiens | 17 | ALA1926564 | assay format | Scientific Literature | |
5. | ALA1932796 | ADME | Clearance in human liver microsomes assessed per mg of protein at 0.5 uM | Homo sapiens | 8 | ALA1926564 | microsome format | Scientific Literature | |
6. | ALA1932797 | ADME | Clearance in Sprague-Dawley rat liver microsomes assessed per mg of protein at 0.5 uM | Rattus norvegicus | 8 | ALA1926564 | microsome format | Scientific Literature | |
7. | ALA1932798 | ADME | Apparent permeability across human Caco2 cells at 10 uM after 2 hrs | Homo sapiens | 5 | ALA1926564 | cell-based format | Scientific Literature | |
8. | ALA1932799 | ADME | Efflux ratio of apparent permeability across human Caco2 cells at 10 uM after 2 hrs | Homo sapiens | 5 | ALA1926564 | cell-based format | Scientific Literature | |
9. | ALA1932800 | Physicochemical | Lipophilicity, log D of the compound at pH 7.4 | 8 | ALA1926564 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA1932801 | ADME | Fraction unbound in rat plasma containing 50% plasma protein | Rattus norvegicus | 5 | ALA1926564 | cell-free format | Scientific Literature |