| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1929950 | B | Inhibition of PDE7A assessed as hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assay | 4 | ALA1926561 | single protein format | Scientific Literature | ||
| 2. | ALA1929951 | F | Antiinflammatory activity against P2 rat astrocytes assessed as inhibition of LPS-induced nitrite production at 30 uM administered 1 hr before LPS challenge measured after 24 hrs by Griess reaction | Rattus norvegicus | 3 | ALA1926561 | cell-based format | Scientific Literature | |
| 3. | ALA1929953 | F | Antiinflammatory activity against rat microglial assessed as inhibition of LPS-induced nitrite production at 30 uM administered 1 hr before LPS challenge measured after 24 hrs by Griess reaction | Rattus norvegicus | 3 | ALA1926561 | assay format | Scientific Literature | |
| 4. | ALA1929956 | F | Antiinflammatory activity against E18 rat primary cortical neurons assessed as inhibition of LPS-induced nitrite production at 30 uM administered 1 hr before LPS challenge measured after 24 hrs by Griess reaction | Rattus norvegicus | 3 | ALA1926561 | cell-based format | Scientific Literature | |
| 5. | ALA1929957 | A | Permeability of the compound after 2.5 hrs by PAMPA-BBB assay | 12 | ALA1926561 | assay format | Scientific Literature | ||
| 6. | ALA1929958 | F | Neuroprotective effect against middle cerebral artery occlusion-induced focal cerebral ischemia in Swiss mouse stroke model assessed as reduction in infarct volume at 5 mg/kg after 15 mins (Rvb = 15.4 +/- 1.1 %) | Mus musculus | 1 | ALA1926561 | organism-based format | Scientific Literature | |
| 7. | ALA3091007 | B | Non-competitive mixed type inhibition of human recombinant PDE7A1 using [3H]AMP after 20 mins by Lineweaver-Burk plot analysis | Homo sapiens | 2 | ALA3085684 | single protein format | Scientific Literature | |
| 8. | ALA3383887 | B | Inhibition of PDE7 (unknown origin) | Homo sapiens | 3 | ALA3352280 | protein format | Scientific Literature | |
| 9. | ALA3383888 | A | Emetogenic potential in surrogate emesis CD1 mouse model assessed as effect on xyclacine/ketamine-induced loss of righting reflex at 0.1 to 10 mg/kg, sc | Mus musculus | 3 | ALA3352280 | organism-based format | Scientific Literature | |
| 10. | ALA5127048 | B | Inhibition of PDE7A (unknown origin) | Homo sapiens | 4 | ALA5126508 | single protein format | Scientific Literature |
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