| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1932646 | F | Antipsychotic activity in ICR mouse assessed as inhibition of (+)-HA966-induced hyperlocomotion at 3 mg/kg, po administered 20 mins prior (+)-HA966] challenge measured every 90 mins | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA1932648 | B | Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting | Rattus norvegicus | 19 | cell-based format | Scientific Literature | ||
| 3. | ALA1932649 | B | Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation counting | Rattus norvegicus | 9 | assay format | Scientific Literature | ||
| 4. | ALA1932650 | B | Selectivity ratio of IC50 for rat GlyT1 to IC50 for rat GlyT2 | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 5. | ALA1932651 | P | Aqueous solubility of the compound at pH 1.2 | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA1932706 | P | Aqueous solubility of the compound at pH 6.8 | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA2421621 | A | Efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side in pig LLC-GA5-COL150 cells transfected with human MDR1 after 2 hrs by LC-MS/MS analysis | Sus scrofa | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA2421622 | A | Efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side in pig LLC-PK1 cells expressing MDR1 after 2 hrs by LC-MS/MS analysis | Sus scrofa | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA2423108 | A | Intrinsic clearance in ddY mouse liver microsomes by LC-MS/MS analysis | Mus musculus | 3 | microsome format | Scientific Literature | ||
| 10. | ALA2423109 | A | Intrinsic clearance in human liver microsomes after 30 mins by LC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 11. | ALA2423110 | P | Lipophilicity, log D of the compound at pH 7.4 | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA2423111 | P | Aqueous solubility of the compound at pH 6.8 after 20 hrs by HPLC analysis | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA2423112 | F | Inhibition of GlyT1 in ICR mouse assessed as inhibition of (+)-HA966-induced hyperlocomotion at 1 mg/kg, po administered 30 mins prior to (+)-HA966 challenge measured after 90 mins | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 14. | ALA2423114 | B | Selectivity ratio of IC50 for GlyT2 in Wistar rat brainstem cells to GlyT1 in rat C6 glioma cells | Rattus norvegicus | 29 | cell-based format | Scientific Literature | ||
| 15. | ALA2423115 | B | Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis | Rattus norvegicus | 29 | cell-based format | Scientific Literature | ||
| 16. | ALA2423116 | B | Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillation counting analysis | Rattus norvegicus | 31 | cell-based format | Scientific Literature | ||
| 17. | ALA2423117 | F | Inhibition of GlyT1 in ICR mouse assessed as inhibition of (+)-HA966-induced hyperlocomotion at 3 mg/kg, po administered 30 mins prior to (+)-HA966 challenge measured after 90 mins | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA2423119 | A | Apparent permeability from apical to basolateral side in pig LLC-PK1 cells expressing MDR1 after 2 hrs by LC-MS/MS analysis | Sus scrofa | 3 | cell-based format | Scientific Literature |
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