# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1936805 | F | Antagonist activity at human MCHR2 receptor expressed in CHO cells assessed as inhibition of MCH-stimulated Ca2+ flux preincubated for 10 mins prior to MCH-stimulation by FLIPR assay | Homo sapiens | 29 | ALA1932960 | cell-based format | Scientific Literature | |
2. | ALA1936806 | B | Displacement of [3H]N-(1'-((9-ethyl-9H-carbazol-3-yl)methyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)acetamide from human MCHR2 expressed in HEK293 cells after 2 hrs | Homo sapiens | 1 | ALA1932960 | cell-based format | Scientific Literature | |
3. | ALA1936807 | B | Binding affinity to MCHR1 up to 10 uM | 1 | ALA1932960 | single protein format | Scientific Literature | ||
4. | ALA1936808 | F | Antagonist activity at MCHR1 up to 50 uM by FLIPR assay | 1 | ALA1932960 | assay format | Scientific Literature | ||
5. | ALA1936809 | B | Inhibition of dopamine D2 receptor | 2 | ALA1932960 | single protein format | Scientific Literature | ||
6. | ALA1936810 | B | Inhibition of serotonin transporter | 2 | ALA1932960 | single protein format | Scientific Literature | ||
7. | ALA1936811 | A | Clearance in rat at 0.5 mg/kg, iv | Rattus norvegicus | 5 | ALA1932960 | organism-based format | Scientific Literature | |
8. | ALA1936812 | A | Mean residence time in rat at 0.5 mg/kg, iv | Rattus norvegicus | 5 | ALA1932960 | organism-based format | Scientific Literature | |
9. | ALA1936813 | A | Oral bioavailability in rat at 2 mg/kg | Rattus norvegicus | 5 | ALA1932960 | organism-based format | Scientific Literature | |
10. | ALA1936814 | A | Clearance in Beagle dog | Canis lupus familiaris | 1 | ALA1932960 | organism-based format | Scientific Literature | |
11. | ALA1936815 | A | Mean residence time in Beagle dog | Canis lupus familiaris | 1 | ALA1932960 | organism-based format | Scientific Literature | |
12. | ALA1936816 | A | Oral bioavailability in Beagle dog at 2 mg/kg | Canis lupus familiaris | 1 | ALA1932960 | organism-based format | Scientific Literature | |
13. | ALA1936817 | A | Clearance in rhesus monkey | Macaca mulatta | 1 | ALA1932960 | organism-based format | Scientific Literature | |
14. | ALA1936818 | A | Mean residence time in rhesus monkey | Macaca mulatta | 1 | ALA1932960 | organism-based format | Scientific Literature | |
15. | ALA1936819 | A | Oral bioavailability in rhesus monkey at 2 mg/kg | Macaca mulatta | 1 | ALA1932960 | organism-based format | Scientific Literature | |
16. | ALA1936820 | B | Selectivity ratio of IC50 for serotonin transporter to IC50 for human MCHR2 receptor | Homo sapiens | 1 | ALA1932960 | assay format | Scientific Literature | |
17. | ALA1936821 | B | Selectivity ratio of IC50 for dopamine D2 receptor to IC50 for human MCHR2 receptor | Homo sapiens | 1 | ALA1932960 | assay format | Scientific Literature | |
18. | ALA1936822 | B | Inhibition of human ERG by rubidium [86Rb] efflux assay | Homo sapiens | 1 | ALA1932960 | single protein format | Scientific Literature |