# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1936046 | F | Growth inhibition of Escherichia coli BW25113 at 100 uM after 40 hrs in presence of glucose as sole carbon source | Escherichia coli | 3 | organism-based format | Scientific Literature | ||
2. | ALA1936047 | B | Non-competitive inhibition of Escherichia coli HinT using tryptamine 5'-adenosine phosphoramidate as substrate compound pre-incubated for 30 secs prior substrate addition measured for 2 mins by Dixon plot analysis | Escherichia coli | 6 | assay format | Scientific Literature | ||
3. | ALA1936048 | B | Non-competitive inhibition of human HinT1 using tryptamine 5'-adenosine phosphoramidate as substrate compound pre-incubated for 30 secs prior substrate addition measured for 2 mins by Dixon plot analysis | Homo sapiens | 6 | single protein format | Scientific Literature | ||
4. | ALA1936049 | B | Inhibition of HinT in Escherichia coli BW25113 assessed as impaired growth at 100 uM after 40 hrs in presence of D,L-alanine as sole carbon source | Escherichia coli | 3 | assay format | Scientific Literature | ||
5. | ALA4432902 | B | Inhibition of His-tagged human full length HINT1 expressed in Rosetta2 pLysS cells using TrpAMP as substrate measured for 2 to 30 mins by fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4432904 | B | Binding affinity to recombinant human HINT1 by isothermal titration calorimetric assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
7. | ALA4476967 | B | Inhibition of human N-terminal His6-tagged Hint1 expressed in Escherichia coli Rosetta 2 pLysS cells by fluorescence assay | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
8. | ALA4476968 | B | Binding affinity to full-length human N-terminal His6-tagged Hint1 expressed in Escherichia coli Rosetta 2 pLysS cells by isothermal titration calorimetry | Homo sapiens | 12 | cell-based format | Patent Bioactivity Data | ||
9. | ALA4476969 | F | Analgesic activity in ICR mouse model of spared nerve injury assessed as reduction in mechanical hypersensitivity at 1 nmol administered intrathecally prior to spared nerve injury by Von Frey test | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
10. | ALA4476970 | F | Analgesic activity in ICR mouse model of spared nerve injury assessed as reduction in mechanical hypersensitivity at 1 nmol administered intrathecally 7 days post spared nerve injury by Von Frey test | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
11. | ALA4476972 | F | Suppression of morphine-induced inhibition of NMDA-evoked mechanical hypersensitivity in ICR mouse administered intrathecally treated 10 mins prior to morphine addition followed by NMDA stimulation for 10 mins and measured for 1 min by tail flick test | Mus musculus | 3 | organism-based format | Patent Bioactivity Data | ||
12. | ALA4476973 | F | Suppression of morphine-induced analgesic tolerance in ICR mouse model of spared nerve injury-induced neuropathic pain assessed as reduction in mechanical hypersensitivity administered intrathecally for 3 days prior to morphine challenge on day 4 by Von Frey test | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
13. | ALA4476974 | F | Effect on spared nerve injury-induced ICR mouse model of neuropathic pain administered intrathecally for 3 days by Von Frey test | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
14. | ALA4476977 | P | Solubility of the compound in DMSO | 6 | small-molecule physicochemical format | Patent Bioactivity Data | |||
15. | ALA4476978 | F | Suppression of morphine-induced analgesic tolerance in ICR mouse model of spared nerve injury-induced neuropathic pain assessed as reduction in mechanical hypersensitivity administered intrathecally for 3 days prior to morphine challenge on day 4 by Von Frey test relative to control | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
16. | ALA4476979 | F | Effect on spared nerve injury-induced ICR mouse model of neuropathic pain administered intrathecally for 3 days by Von Frey test relative to control | Mus musculus | 2 | organism-based format | Patent Bioactivity Data |