| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1936798 | B | Inhibition of BCRP in human MCF7/MX cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by Fluorometry | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
| 2. | ALA1936799 | B | Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
| 3. | ALA1936270 | B | Inhibition of MDR1 in human A2780adr cells assessed as calcein AM accumulation at 10 uM by fluorimetry | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 4. | ALA1936271 | B | Inhibition of MRP1 overexpressed in human 2008 MRP1 cells assessed as calcein AM accumulation at 10 uM by fluorimetry | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 5. | ALA3587196 | B | Inhibition of TNF-alpha-induced NF-kappaB transcriptional activation in human MDA-MB-231 cells after 8 hrs by NF-kappaB cis-acting reporter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3587197 | A | Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 24 hrs by Cell Counting kit-8 assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA3587198 | B | Inhibition of TNF-alpha-induced IKKalpha/beta phosphorylation at Ser176/180 in human MDA-MB-231 cells after 20 mins by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA3587199 | B | Inhibition of TNF-alpha-induced IkB-alpha phosphorylation at Ser32 in human MDA-MB-231 cells after 60 mins by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA3587200 | B | Inhibition of TNF-alpha-induced Rel-A phosphorylation at Ser536 in human MDA-MB-231 cells after 60 mins by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA3587201 | B | Inhibition of TNF-alpha-induced Rel-A nuclear translocation in human MDA-MB-231 cells assessed as decrease in Rel-A phoshorylation at Ser536 at 20 uM pretreated for 30 mins prior to TNF-alpha stimulation measured after 60 mins by immunofluorescence microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA3587202 | F | Decrease in TNF-alpha-induced MMP-9 gene expression in human MDA-MB-231 cells after 12 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA3587203 | F | Decrease in TNF-alpha-induced MMP-9 mRNA expression in human MDA-MB-231 cells at 20 uM after 12 hrs by quantitative real time PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3587204 | F | Decrease in TNF-alpha-induced MMP-9 mRNA expression in human MDA-MB-231 cells assessed as MMP-9 mRNA level at 20 uM after 12 hrs by quantitative real time PCR analysis relative to untreated control (Rvb = 16 No_unit) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3587205 | B | Inhibition of TNF-alpha-induced NF-kappaB mediated MMP9 activation in human MDA-MB-231 cells at 10 to 20 uM after 24 hrs by in-gel gelatinase activity assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA3587206 | B | Inhibition of TNF-alpha-induced NF-kappaB-mediated MMP9 promoter-reporter activation in human MDA-MB-231 cells after 8 hrs by luciferase assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3587207 | F | Inhibition of TNF-alpha-induced cell invasion of human MDA-MB-231 cells at 20 uM after 4 days by three dimensional spheroid invasion assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4130642 | B | Activation of Nrf2 in wild type mouse Hepa1c1c7 cells cytosolic fraction assessed as induction of quinone reductase activity at 10 uM using 2,6-DCIP as substrate in presence of NADH incubated for 48 hrs measured for 1 min relative to control | Mus musculus | 22 | assay format | Scientific Literature | ||
| 18. | ALA4130643 | B | Activation of Nrf2 in mutant mouse BpRc1 cells cytosolic fraction assessed as induction of quinone reductase activity at 10 uM using 2,6-DCIP as substrate in presence of NADH incubated for 48 hrs measured for 1 min relative to control | Mus musculus | 22 | cell-based format | Scientific Literature | ||
| 19. | ALA4130644 | B | Ratio of activation of wild type Nrf2 in mouse Hepa1c1c7 cells cytosolic fraction to activation of Nrf2 in mutant mouse BpRc1 cells cytosolic fraction | Mus musculus | 22 | cell-based format | Scientific Literature | ||
| 20. | ALA4130653 | F | Cytotoxicity against human MCF7 cells assessed as cell survival at 100 uM after 24 hrs by SRB assay relative to control | Homo sapiens | 20 | cell-based format | Scientific Literature |
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