1. ALA1947970 A Half life in CD-1 mouse liver microsomes at 1 uM by LC-MS/MS analysis Mus musculus 6 microsome format Scientific Literature 2. ALA1947971 A Intrinsic clearance in CD-1 mouse liver microsomes at 1 uM by LC-MS/MS analysis Mus musculus 6 microsome format Scientific Literature 3. ALA1947972 P Solubility of the compound in PBS buffer at pH 7.4 after 24 hrs by LC-MS analysis 6 small-molecule physicochemical format Scientific Literature 4. ALA1947973 B Inhibition of EthR binding to ethA promoter in 106-bp biotinylated DNA preincubated for 5 mins measured for 3 mins by surface plasmon resonance assay 6 single protein format Scientific Literature 5. ALA1947974 B Inhibition of Mycobacterium tuberculosis H37Rv EthR in Mycobacterium tuberculosis H37Rv expressing GFP infected mouse in RAW264.7 cells assessed as potentiation of ethionamide-induced antitubercular activity after 5 days by SYTO60-based fluorescence microscopy Mycobacterium tuberculosis H37Rv 41 cell-based format Scientific Literature 6. ALA1947976 A AUC (0 to infinity) in CD-1 mouse at 20 mg/kg, po administered with aqueous solution of 100 mM hydroxypropyl-beta-cyclodextrin by LC-MS/MS analysis Mus musculus 2 organism-based format Scientific Literature 7. ALA1948070 A Ratio of plasma concentration in CD-1 mouse at 20 mg/kg, po administered with aqueous solution of 100 mM hydroxypropyl-beta-cyclodextrin after 4 hrs to EC50 for inhibition of Mycobacterium tuberculosis H37Rv EthR 2 organism-based format Scientific Literature 8. ALA4296184 F Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020); MIC in CAMBH media, using NBS plates, by OD(600) Staphylococcus aureus 4,588 organism-based format CO-ADD antimicrobial screening data 9. ALA4296185 F Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CAMBH media using NBS plates, by OD(600) Escherichia coli 4,585 organism-based format CO-ADD antimicrobial screening data 10. ALA4296186 F Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); MIC in CAMBH media using NBS plates, by OD(600) Klebsiella pneumoniae 6,160 organism-based format CO-ADD antimicrobial screening data 11. ALA4296187 F Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC in CAMBH media using NBS plates, by OD(600) Pseudomonas aeruginosa 24,161 organism-based format CO-ADD antimicrobial screening data 12. ALA4296188 F Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MIC in CAMBH media using NBS plates, by OD600 Acinetobacter baumannii 22,588 organism-based format CO-ADD antimicrobial screening data 13. ALA4296189 F Antifungal activity against Candida albicans ATCC 90028 (CO-ADD:FG_001); MIC in YNB media using NBS plates, by OD630 Candida albicans 6,134 organism-based format CO-ADD antimicrobial screening data 14. ALA4296190 F Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 (CO-ADD:FG_002); MIC in YNB media using NBS plates, by Resazurin OD(600-570) Cryptococcus neoformans 6,133 organism-based format CO-ADD antimicrobial screening data 15. ALA4296191 F Cytotoxicity against HEK293 cells (CO-ADD:MA_007); CC50 by cell viability assay in DMEM (10% FBS) media using TC plates, by Resazurin F(560/590) Homo sapiens 899 cell-based format CO-ADD antimicrobial screening data 16. ALA4296784 F Haemolysis of human Red Blood Cells (CO-ADD:HA_150); HC10, by OD(450) Homo sapiens 490 cell-based format CO-ADD antimicrobial screening data 17. ALA4296802 F Antibacterial activity against Pseudomonas aeruginosa PAO397 [PAO1 d(mexAB-oprM) d(mexCD-oprJ) d(mexEF-oprN) d(mexJKL) d(mexXY) d(opmH)] (CO-ADD:GN_211); MIC in CAMBH media using NBS plates, by OD(600) Pseudomonas aeruginosa 18,406 organism-based format CO-ADD antimicrobial screening data 18. ALA4434519 B Inhibition of Mycobacterium tuberculosis H37Rv EthR Mycobacterium tuberculosis H37Rv 1 single protein format Scientific Literature