| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1953081 | A | Inhibition of recombinant human CYP3A4 in supersomes using midazolam as substrate after 5 mins by LC-MS/MS analysis | Homo sapiens | 39 | single protein format | Scientific Literature | ||
| 2. | ALA1953082 | A | Inhibition of recombinant human CYP3A5 in supersomes using midazolam as substrate after 5 mins by LC-MS/MS analysis | Homo sapiens | 23 | single protein format | Scientific Literature | ||
| 3. | ALA1953086 | A | Selectivity ratio of IC50 for human CYP3A5 to IC50 for human CYP3A4 | Homo sapiens | 24 | assay format | Scientific Literature | ||
| 4. | ALA3411298 | B | Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATP | Homo sapiens | 45 | single protein format | Scientific Literature | ||
| 5. | ALA3411299 | B | Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATP | Homo sapiens | 42 | single protein format | Scientific Literature | ||
| 6. | ALA3411300 | B | Selectivity index, ratio of IC50 for human ROCK2 to IC50 for Limk1 | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 7. | ALA3411301 | B | Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATP | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 8. | ALA3411302 | B | Inhibition of human JNK3 using ATF2 substrate, ATP and [gamma33P]ATP | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 9. | ALA3411303 | A | Inhibition of CYP1A2 (unknown origin) assessed as reduction in phenaceten demethylation to acetaminophen at 10 uM | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 10. | ALA3411304 | A | Inhibition of CYP2C9 (unknown origin) assessed as reduction in tolbutamide hydroxylation to hydrocytolbutamide at 10 uM | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 11. | ALA3411305 | A | Inhibition of CYP2D6 (unknown origin) assessed as reduction in bufuralol hydroxylation to 4'-Hydroxybufuralol at 10 uM | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 12. | ALA3411306 | A | Inhibition of CYP3A4 (unknown origin) assessed as reduction in midazolam hydroxylation to 1'-Hydroxymidazolam at 10 uM | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 13. | ALA3411313 | A | Half life in human liver microsomes | Homo sapiens | 15 | assay format | Scientific Literature | ||
| 14. | ALA3411314 | A | Half life in rat liver microsomes | Rattus norvegicus | 15 | assay format | Scientific Literature | ||
| 15. | ALA3411315 | B | Inhibition of Limk1 in rat A7r5 cells assessed as reduction in cofilin phosphorylation by Western blot method | Rattus norvegicus | 15 | cell-based format | Scientific Literature | ||
| 16. | ALA3411319 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS and HPLC method | Rattus norvegicus | 14 | organism-based format | Scientific Literature | ||
| 17. | ALA3411320 | A | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS and HPLC method | Rattus norvegicus | 14 | organism-based format | Scientific Literature | ||
| 18. | ALA3411321 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS and HPLC method | Rattus norvegicus | 14 | organism-based format | Scientific Literature | ||
| 19. | ALA3411322 | A | AUC in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS and HPLC method | Rattus norvegicus | 14 | organism-based format | Scientific Literature | ||
| 20. | ALA3411323 | A | Cmax in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS and HPLC method | Rattus norvegicus | 14 | organism-based format | Scientific Literature |
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