# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2160405 | Binding | Inhibition of human ERG by patch clamp assay | Homo sapiens | 4 | ALA2157870 | assay format | Scientific Literature | |
2. | ALA2160408 | Functional | Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by MSF assay | Plasmodium falciparum | 6 | ALA2157870 | organism-based format | Scientific Literature | |
3. | ALA2160409 | Functional | Antimalarial activity against Plasmodium falciparum K1 after 72 hrs by MSF assay | Plasmodium falciparum | 6 | ALA2157870 | organism-based format | Scientific Literature | |
4. | ALA2160410 | Binding | Inhibition of Nav1.5 assessed as tonic inhibition by patch clamp assay | 3 | ALA2157870 | assay format | Scientific Literature | ||
5. | ALA2160411 | Binding | Inhibition of Nav1.5 assessed as phasic inhibition by patch clamp assay | 3 | ALA2157870 | assay format | Scientific Literature | ||
6. | ALA2160412 | Binding | Inhibition of Kir6.2 by patch clamp assay | 3 | ALA2157870 | assay format | Scientific Literature | ||
7. | ALA2160413 | ADME | Therapeutic index, ratio of IC50 for human ERG to EC50 for Plasmodium falciparum K1 | 4 | ALA2157870 | assay format | Scientific Literature | ||
8. | ALA2160414 | ADME | Inhibition of CYP2D6 in human liver microsomes at 1 uM after 20 mins by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA2157870 | microsome format | Scientific Literature | |
9. | ALA2160415 | ADME | Inhibition of CYP2D6 in human liver microsomes at 10 uM after 20 mins by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA2157870 | microsome format | Scientific Literature | |
10. | ALA2160416 | ADME | Permeability of the compound at 10 uM at pH 7.4 by PAMPA | 7 | ALA2157870 | assay format | Scientific Literature | ||
11. | ALA2160417 | Physicochemical | Solubility of the compound in PBS at 10 mM after 18 hrs by UV spectroscopic analysis | 7 | ALA2157870 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA2160418 | ADME | Intrinsic clearance in CD9 mouse liver microsomes at 2 mM | Mus musculus | 7 | ALA2157870 | microsome format | Scientific Literature | |
13. | ALA2160419 | ADME | Intrinsic clearance in human liver microsomes at 2 mM | Homo sapiens | 7 | ALA2157870 | microsome format | Scientific Literature | |
14. | ALA2160420 | ADME | Cmax in CD1 mouse at 20 mg/kg, po | Mus musculus | 6 | ALA2157870 | organism-based format | Scientific Literature | |
15. | ALA2160421 | ADME | Cmax in CD1 mouse at 200 mg/kg, po | Mus musculus | 6 | ALA2157870 | organism-based format | Scientific Literature | |
16. | ALA2160423 | ADME | Tmax in CD1 mouse at 20 mg/kg, po | Mus musculus | 6 | ALA2157870 | organism-based format | Scientific Literature | |
17. | ALA2160424 | ADME | Tmax in CD1 mouse at 200 mg/kg, po | Mus musculus | 6 | ALA2157870 | organism-based format | Scientific Literature | |
18. | ALA2160426 | ADME | AUC (0 to infinity) in CD1 mouse at 20 mg/kg, po | Mus musculus | 6 | ALA2157870 | organism-based format | Scientific Literature | |
19. | ALA2160427 | ADME | AUC (0 to infinity) in CD1 mouse at 200 mg/kg, po | Mus musculus | 6 | ALA2157870 | organism-based format | Scientific Literature | |
20. | ALA2160429 | ADME | Apparent volume of distribution during terminal phase in CD1 mouse at 20 mg/kg, po | Mus musculus | 6 | ALA2157870 | organism-based format | Scientific Literature |