GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM
GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM
GSK_TCMDC: Inhibition Frequency Index (IFI). The number of non-kinase HTS assays where a compound showed > 50 % inhibition, expressed as a percentage of the number of such assays in which the compound was tested
Antimalarial activity against Plasmodium gallinaceum infected in mouse assessed as quinine equivalent to dose required to suppress parasitemia by 75% compound treated through gavage for 3 days
Antimalarial activity against Plasmodium gallinaceum parent strain infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days
Antimalarial activity against chloroquine-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days
Antimalarial activity against cycloguanil-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days
Antimalarial activity against DDS-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days
Antimalarial activity against chloroquine-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days relative to parent strain
Antimalarial activity against cycloguanil-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days relative to parent strain
Antimalarial activity against DDS-resistant Plasmodium gallinaceum infected in mouse assessed as dose required to suppress parasitemia by 90% compound treated through gavage for 3 days relative to parent strain
Antimalarial activity against chloroquine-sensitive, pyrimethamine-resistant Plasmodium falciparum Malayan Camp CH/Q infected in Aotus monkey assessed as dose required to >50% cures compound treated for 7 days
Antimalarial activity against chloroquine-resistant, pyrimethamine-sensitive Plasmodium falciparum Vietnam Oak Knoll in Aotus monkey assessed as dose required to >50% cures compound treated for 7 days