# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2020459 | B | Blockade of human full-length NaV1.5 expressed in HEK293 cells co-transfected with pCD8-IRES-hbeta1 assessed as 0.1 Hz of half-maximal tonic-induced channel current at -120 mV holding potential after 36 to 72 hrs by patch clamp assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA2020460 | B | Blockade of human full-length NaV1.5 expressed in HEK293 cells co-transfected with pCD8-IRES-hbeta1 assessed as 10 Hz of use-dependent-induced channel current at -120 mV holding potential after 36 to 72 hrs by patch clamp assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA2020461 | B | Ratio of mexiletine IC50 to compound IC50 for human full-length NaV1.2 at half maximal tonic block | Homo sapiens | 1 | single protein format | Scientific Literature | ||
4. | ALA2020462 | B | Ratio of mexiletine IC50 to compound IC50 for human full-length NaV1.2 at phasic block | Homo sapiens | 1 | single protein format | Scientific Literature | ||
5. | ALA2020464 | F | Antiarrhythmic activity in guinea pig left atria assessed as increase of 1 Hz-induced alternating current arrhythmia at 10'-4 M after 60 mins relative to control | Cavia porcellus | 3 | tissue-based format | Scientific Literature | ||
6. | ALA2020465 | F | Antiarrhythmic activity in guinea pig left atria assessed as increase of 1 Hz-induced alternating current arrhythmia after 60 mins | Cavia porcellus | 3 | tissue-based format | Scientific Literature | ||
7. | ALA2020469 | F | Negative inotropic activity in guinea pig left atria assessed as decrease of 1 Hz current-induced developed tension at 5 x 10'-5 M relative to control | Cavia porcellus | 2 | tissue-based format | Scientific Literature | ||
8. | ALA2020471 | F | Negative chronotropic activity in guinea pig spontaneously beating right atria assessed as decrease in atrial rate at 10'-4 M relative to control | Cavia porcellus | 2 | tissue-based format | Scientific Literature | ||
9. | ALA2020474 | F | Negative inotropic activity in guinea pig left atria assessed as decrease of 1 Hz current-induced developed tension | Cavia porcellus | 5 | tissue-based format | Scientific Literature | ||
10. | ALA2020476 | F | Vasorelaxant activity in potassium depolarized guinea pig aortic strip assessed as inhibition of calcium-induced contraction at 10'-4 M | Cavia porcellus | 6 | tissue-based format | Scientific Literature | ||
11. | ALA2020477 | T | Neurotoxicity in mouse assessed as deffect in motor coordination at 25 to 50 mg/kg, po after 15 to 45 mins by rotarod test | Mus musculus | 2 | organism-based format | Scientific Literature | ||
12. | ALA2020478 | A | Cytotoxicity against human HepG2 cells assessed as cell viability after 2 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA2020529 | A | Apparent permeability from apical to basolateral side in human Caco2 cells after 21 days by UV spectroscopy | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA2020530 | A | Apparent permeability from basolateral to apical side in human Caco2 cells after 21 days by UV spectroscopy | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA2020531 | A | Efflux ratio of permeability from basolateral to apical side to apical to basolateral side in human Caco2 cells after 21 days by UV spectroscopy | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA2406642 | F | Relaxtant activity in guinea pig K+-depolarized ileum longitudinal smooth muscle assessed as inhibition of calcium-induced contraction at 10'-4 M relative to control | Cavia porcellus | 4 | tissue-based format | Scientific Literature | ||
17. | ALA2406643 | F | Relaxtant activity in guinea pig K+-depolarized ileum longitudinal smooth muscle assessed as inhibition of calcium-induced contraction | Cavia porcellus | 3 | tissue-based format | Scientific Literature |