# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2026785 | B | Inhibition of kynurenine-3-hydroxylase in rat liver homogenates assessed as effect on production of 3-hydroxy kynurenine incubated for 1 hr by HPLC | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
2. | ALA2026786 | B | Inhibition of kynurenine-3-hydroxylase in rat liver homogenates assessed as effect on production of 3-hydroxy kynurenine up to 125 uM incubated for 1 hr by HPLC | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
3. | ALA2026787 | B | Inhibition of kynureninase in rat liver homogenates assessed as effect on production of anthranilic acid up to 125 uM incubated for 30 mins by HPLC | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
4. | ALA2026788 | B | Inhibition of kynureninase in rat liver homogenates assessed as effect on production of anthranilic acid at >125 uM incubated for 30 mins by HPLC | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
5. | ALA2026789 | F | Effect on extracellular kynurenic acid in rat brain dosed at 200 mg/kg, ip by in-vivo microdialysis measured for 6 hrs post dose (Rvb = 1.55 +/- 0.05 pg/ml) | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
6. | ALA2026941 | F | Inhibition of of kynurenine-3-hydroxylase in rat brain assessed as increase in Increase in extracellular kynurenic acid level at 200 mg/kg, ip coadministered with 100 mg/kg kynurenine by in-vivo microdialysis measured within 25 mins post dose relative to untreated control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
7. | ALA2026942 | F | Inhibition of of kynurenine-3-hydroxylase in rat brain assessed as increase in Increase in extracellular kynurenic acid level at 200 mg/kg, ip coadministered with 100 mg/kg kynurenine by in-vivo microdialysis measured at 135 mins post dose relative to untreated control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
8. | ALA2026943 | F | Inhibition of of kynurenine-3-hydroxylase in rat brain assessed as increase in Increase in extracellular kynurenic acid level at 200 mg/kg, ip coadministered with 100 mg/kg kynurenine by in-vivo microdialysis measured up to 335 mins post dose relative to untreated control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
9. | ALA2026944 | F | Inhibition of of kynurenine-3-hydroxylase in rat brain assessed as increase in Increase in extracellular kynurenic acid level at 200 mg/kg, ip coadministered with 100 mg/kg kynurenine by in-vivo microdialysis measured at 5 hrs post dose relative to untreated control | Rattus norvegicus | 1 | organism-based format | Scientific Literature |