| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2034218 | F | Ex-vivo inhibition of po dosed mouse PrCP by FRET analysis in presence of heat inactivated 25% plasma | Mus musculus | 16 | organism-based format | Scientific Literature | ||
| 2. | ALA2034219 | F | Ex-vivo inhibition of po dosed mouse PrCP by FRET analysis in absence of plasma | Mus musculus | 16 | organism-based format | Scientific Literature | ||
| 3. | ALA2034220 | B | Inhibition of human PrCP | Homo sapiens | 23 | single protein format | Scientific Literature | ||
| 4. | ALA2034221 | B | Inhibition of mouse PrCP | Mus musculus | 22 | single protein format | Scientific Literature | ||
| 5. | ALA2034226 | A | Clearance in mouse at 1 mg/kg, iv and 30 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA2034227 | A | Volume of distribution in mouse at 1 mg/kg, iv and 30 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA2034228 | A | Half life in mouse at 1 mg/kg, iv and 30 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA2034229 | A | Dose normalized AUC in mouse at 1 mg/kg, iv and 30 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA2034317 | A | Oral bioavailability in mouse at 30 mg/kg | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA2034318 | F | Ex-vivo inhibition of po dosed mouse PrCP by FRET analysis in presence of heat inactivated 100% plasma | Mus musculus | 16 | organism-based format | Scientific Literature | ||
| 11. | ALA2034319 | F | Plasma shift, ratio of Ki for PrCP in presence of heat inactivated 100% plasma of po dosed mouse to Ki for po dosed mouse PrCP in absence of plasma | Mus musculus | 16 | organism-based format | Scientific Literature | ||
| 12. | ALA2034320 | A | Drug uptake in C57 mouse plasma at 30 mg/kg, po after 20 hrs by LC/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA2034323 | A | Drug uptake in C57 mouse brain at 30 mg/kg, po after 20 hrs by LC/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA2034326 | A | Ratio of drug uptake in brain to plasma of C57 mouse at 30 mg/kg, po after 20 hrs by LC/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA2034329 | F | Ex-vivo inhibition of PrCP in heat inactivated 100% plasma of C57 mouse assessed as target engagement at 30 mg/kg, po after 20 hrs by FRET analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA2034332 | F | Ex-vivo inhibition of PrCP in heat inactivated 100% plasma of C57 mouse assessed as target engagement calculated as [cmpd]plasma/([cmpd]plasma + Ki (heat inactivated plasma))x100 at 30 mg/kg, po after 20 hrs by FRET analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA2034335 | F | Ex-vivo inhibition of PrCP in heat inactivated 100% plasma of C57 mouse assessed as efficacy index calculated as ratio of [cmpd]plasma to (%free fraction)/(dose x mouse IC50) at 30 mg/kg, po after 20 hrs by FRET analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA2034338 | A | Apparent permeability across pig LLC-PK1 cells at 1 uM | Sus scrofa | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA2034339 | A | Ratio of apparent permeability from basolateral to apical side over apical to basolateral side in mouse LLC cells expressing MDR1a at 1 uM | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA2026494 | B | Inhibition of human PrCP | Homo sapiens | 37 | single protein format | Scientific Literature |
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