# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2027041 | B | Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA | Homo sapiens | 18 | ALA2021804 | cell-based format | Scientific Literature | |
2. | ALA2027167 | B | Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA | Mus musculus | 18 | ALA2021804 | cell-based format | Scientific Literature | |
3. | ALA2027168 | B | Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA | Homo sapiens | 4 | ALA2021804 | cell-based format | Scientific Literature | |
4. | ALA2027169 | B | Inhibition of mouse 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA | Mus musculus | 4 | ALA2021804 | cell-based format | Scientific Literature | |
5. | ALA2027170 | B | Selectivity ratio of IC50 for human 11beta-HSD1 expressed in HEK293 cells to IC50 for mouse 11beta-HSD1 expressed in HEK293 cells | 5 | ALA2021804 | cell-based format | Scientific Literature | ||
6. | ALA2027171 | B | Selectivity ratio of IC50 for human 11beta-HSD2 expressed in HEK293 cells to IC50 for human 11beta-HSD1 expressed in HEK293 cells | Homo sapiens | 1 | ALA2021804 | cell-based format | Scientific Literature | |
7. | ALA2027172 | A | Tmax in po dosed Sprague-Dawley rat | Rattus norvegicus | 2 | ALA2021804 | organism-based format | Scientific Literature | |
8. | ALA2027173 | A | Cmax in po dosed Sprague-Dawley rat | Rattus norvegicus | 2 | ALA2021804 | organism-based format | Scientific Literature | |
9. | ALA2027174 | A | AUC (0 to t) in po dosed Sprague-Dawley rat | Rattus norvegicus | 2 | ALA2021804 | organism-based format | Scientific Literature | |
10. | ALA2027175 | A | AUC (0 to infinity) in po dosed Sprague-Dawley rat | Rattus norvegicus | 2 | ALA2021804 | organism-based format | Scientific Literature | |
11. | ALA2027176 | A | Mean residence time in po dosed Sprague-Dawley rat | Rattus norvegicus | 2 | ALA2021804 | organism-based format | Scientific Literature | |
12. | ALA2027177 | A | Half life in po dosed Sprague-Dawley rat | Rattus norvegicus | 2 | ALA2021804 | organism-based format | Scientific Literature | |
13. | ALA2027178 | A | AUC in Sprague-Dawley rat at 5 mg/kg, po | Rattus norvegicus | 1 | ALA2021804 | organism-based format | Scientific Literature | |
14. | ALA2027179 | F | Antidiabetic activity in ob/ob mouse type 2 diabetes model assessed as reduction in nonfasting blood glucose level at 50 mg/kg, ip once daily for 5 days | Mus musculus | 1 | ALA2021804 | organism-based format | Scientific Literature | |
15. | ALA2027180 | F | Antidiabetic activity in ob/ob mouse type 2 diabetes model assessed as reduction in fasting blood glucose level at 50 mg/kg, ip once daily for 5 days measured on day 10 | Mus musculus | 1 | ALA2021804 | organism-based format | Scientific Literature | |
16. | ALA2027181 | F | Antidiabetic activity in ob/ob mouse type 2 diabetes model assessed as reduction in fasting blood glucose level at 50 mg/kg, ip once daily for 5 days measured on day 15 | Mus musculus | 1 | ALA2021804 | organism-based format | Scientific Literature | |
17. | ALA2027182 | F | Antidiabetic activity in ob/ob mouse type 2 diabetes model assessed as reduction in fasting blood glucose level at 50 mg/kg, ip once daily for 5 days measured on day 20 | Mus musculus | 1 | ALA2021804 | organism-based format | Scientific Literature | |
18. | ALA2027183 | F | Antidiabetic activity in ob/ob mouse type 2 diabetes model assessed as reduction in blood glucose level at 50 mg/kg, ip once daily for 5 days measured on day 10 | Mus musculus | 1 | ALA2021804 | organism-based format | Scientific Literature | |
19. | ALA2027184 | F | Antidiabetic activity in ob/ob mouse type 2 diabetes model assessed as reduction in blood glucose level at 50 mg/kg, ip once daily for 5 days measured on day 15 | Mus musculus | 1 | ALA2021804 | organism-based format | Scientific Literature | |
20. | ALA2027185 | F | Antidiabetic activity in ob/ob mouse type 2 diabetes model assessed as reduction in blood glucose level at 50 mg/kg, ip once daily for 5 days measured on day 20 | Mus musculus | 1 | ALA2021804 | organism-based format | Scientific Literature |