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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA2037944 Functional Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation Homo sapiens 37 ALA2034879 cell-based format Scientific Literature 2. ALA2037945 Functional Agonist activity at human GPR109b Homo sapiens 7 ALA2034879 assay format Scientific Literature 3. ALA2037946 Functional Agonist activity at rat GPR109a Rattus norvegicus 7 ALA2034879 assay format Scientific Literature 4. ALA2037947 Functional Agonist activity at mouse GPR109a Mus musculus 7 ALA2034879 assay format Scientific Literature 5. ALA2037948 Functional Agonist activity at dog GPR109a Canis lupus familiaris 7 ALA2034879 assay format Scientific Literature 6. ALA2037949 Functional Antidyslipidemic activity in fasted Sprague-Dawley rat assessed as reduction in free fatty acid level in plasma at 1 mg/kg, po after 1 hr relative to vehicle-treated control Rattus norvegicus 5 ALA2034879 organism-based format Scientific Literature 7. ALA2037950 Functional Antidyslipidemic activity in fasted Sprague-Dawley rat assessed as reduction in triglyceride level in plasma at 1 mg/kg, po after 1 hr relative to vehicle-treated control Rattus norvegicus 5 ALA2034879 organism-based format Scientific Literature 8. ALA2037955 Functional Antidyslipidemic activity in fasted beagle dog assessed as reduction in free fatty acid level in plasma at 1 mg/kg, po after 1 hr relative to vehicle-treated control Canis lupus familiaris 3 ALA2034879 organism-based format Scientific Literature 9. ALA2038314 ADME AUC (0 to 24 hrs) in Sprague-Dawley rat at 5 mg/kg, po Rattus norvegicus 1 ALA2034879 organism-based format Scientific Literature 10. ALA2038315 ADME Oral bioavailability in Sprague-Dawley rat at 5 mg/kg Rattus norvegicus 1 ALA2034879 organism-based format Scientific Literature 11. ALA2038316 Functional Antidyslipidemic activity in po dosed fasted Sprague-Dawley rat assessed as reduction in free fatty acid level in plasma Rattus norvegicus 2 ALA2034879 organism-based format Scientific Literature 12. ALA2038317 Functional Antidyslipidemic activity in po dosed fasted Sprague-Dawley rat assessed as reduction in triglyceride level in plasma Rattus norvegicus 1 ALA2034879 organism-based format Scientific Literature 13. ALA2038318 Functional Antidyslipidemic activity in fasted Sprague-Dawley rat assessed as reduction in free fatty acid level in plasma at 3 mg/kg, po up to 2 hrs Rattus norvegicus 1 ALA2034879 organism-based format Scientific Literature 14. ALA2038319 Functional Antidyslipidemic activity in fasted Sprague-Dawley rat assessed as reduction in free fatty acid level in plasma at 3 mg/kg, po after 2 hrs Rattus norvegicus 1 ALA2034879 organism-based format Scientific Literature 15. ALA2038320 Toxicity Toxicity in fasted beagle dog assessed as flushing at 1 to 10 mg/kg, po Canis lupus familiaris 1 ALA2034879 organism-based format Scientific Literature 16. ALA2038321 Toxicity Toxicity in fasted beagle dog assessed as change in skin colour at 1 to 10 mg/kg, po Canis lupus familiaris 1 ALA2034879 organism-based format Scientific Literature 17. ALA2038322 Toxicity Toxicity in fasted beagle dog assessed as behavioural changes at 1 to 10 mg/kg, po Canis lupus familiaris 1 ALA2034879 organism-based format Scientific Literature 18. ALA2038323 Toxicity Toxicity in fasted beagle dog assessed as increase in cutaneous blood flow at 30 mg/kg, po relative to control Canis lupus familiaris 1 ALA2034879 organism-based format Scientific Literature 19. ALA2038324 Toxicity Toxicity in fasted beagle dog assessed as behavioural changes at 30 mg/kg, po relative to control Canis lupus familiaris 1 ALA2034879 organism-based format Scientific Literature 20. ALA2038325 Toxicity Nephrotoxicity in CD1 mouse at 100 mg/kg, po administered qd for 5 days measured 2 hrs post-last dose Mus musculus 1 ALA2034879 organism-based format Scientific Literature