# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2039222 | B | Inhibition of RGS4 interaction with Galpha0 protein by flow cytometry protein interaction assay | 41 | ALA2034949 | single protein format | Scientific Literature | ||
2. | ALA2039223 | B | Inhibition of RGS8 interaction with Galpha0 protein by flow cytometry protein interaction assay | 41 | ALA2034949 | single protein format | Scientific Literature | ||
3. | ALA2039224 | B | Selectivity ratio of IC50 for RGS8 to IC50 RGS4 | 40 | ALA2034949 | assay format | Scientific Literature | ||
4. | ALA3706279 | B | Inhibitory Assay: FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyplex high throughput screen to identify inhibitors of the RGS-Gα interaction [4]. This activity was confirmed by analyzing the effect of CCG-50014 on several different RGS proteins with freshly reordered compound using multiplexed FCPIA. CCG-50014 fully inhibited several different RGS proteins including RGS4, 8, 16, and 19, but did not have activity on RGS7 or a mutated form of RGS4 that lacks cysteine residues. | 4 | ALA3639039 | single protein format | BindingDB Database | ||
5. | ALA3707997 | B | Inhibitory Assay: FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyplex high throughput screen to identify inhibitors of the RGS-Gα interaction [4]. This activity was confirmed by analyzing the effect of CCG-50014 on several different RGS proteins with freshly reordered compound using multiplexed FCPIA. CCG-50014 fully inhibited several different RGS proteins including RGS4, 8, 16, and 19, but did not have activity on RGS7 or a mutated form of RGS4 that lacks cysteine residues. | Homo sapiens | 4 | ALA3639039 | single protein format | BindingDB Database |