| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2044828 | B | Inhibition of human recombinant PDE7A1-mediated [3H]cAMP hydrolysis at 10 uM after 20 mins by scintillation proximity assay | Homo sapiens | 29 | ALA2040739 | single protein format | Scientific Literature | |
| 2. | ALA2044829 | B | Competitive inhibition of human recombinant PDE7A1 using 5 nM to 2 uM cAMP as substrate by Lineweaver-Burk plot analysis | Homo sapiens | 2 | ALA2040739 | single protein format | Scientific Literature | |
| 3. | ALA2044986 | B | Inhibition of human recombinant PDE7A1-mediated [3H]cAMP hydrolysis after 20 mins by scintillation proximity assay | Homo sapiens | 8 | ALA2040739 | single protein format | Scientific Literature | |
| 4. | ALA2044987 | A | Cytotoxicity against rat microglia cells at 5 to 10 uM after 16 hrs by MTT assay | Rattus norvegicus | 6 | ALA2040739 | cell-based format | Scientific Literature | |
| 5. | ALA2044988 | A | Cytotoxicity against rat astrocytes at 5 to 10 uM after 16 hrs by MTT assay | Rattus norvegicus | 6 | ALA2040739 | cell-based format | Scientific Literature | |
| 6. | ALA2044989 | F | Antiinflammatory activity in rat microglia cells assessed as inhibition of LPS-induced nitrite production at 5 to 10 uM incubated for 1 hr prior to LPS-challenge measured after 24 hrs by Griess method | Rattus norvegicus | 6 | ALA2040739 | cell-based format | Scientific Literature | |
| 7. | ALA2044990 | F | Antiinflammatory activity in rat astrocytes assessed as inhibition of LPS-induced nitrite production at 5 to 10 uM incubated for 1 hr prior to LPS-challenge measured after 24 hrs by Griess method | Rattus norvegicus | 6 | ALA2040739 | cell-based format | Scientific Literature | |
| 8. | ALA2044993 | B | Inhibition of human recombinant PDE3A-mediated [3H]cAMP hydrolysis at 10 uM after 20 mins by scintillation proximity assay | Homo sapiens | 6 | ALA2040739 | single protein format | Scientific Literature | |
| 9. | ALA2044994 | B | Inhibition of human recombinant PDE3A-mediated [3H]cAMP hydrolysis after 20 mins by scintillation proximity assay | Homo sapiens | 6 | ALA2040739 | single protein format | Scientific Literature | |
| 10. | ALA2044995 | B | Selectivity index, ratio of IC50 for human recombinant PDE7A1 to IC50 for human recombinant PDE3A | Homo sapiens | 6 | ALA2040739 | assay format | Scientific Literature | |
| 11. | ALA2044996 | B | Selectivity index, ratio of IC50 for human recombinant PDE3A to IC50 for human recombinant PDE7A1 | Homo sapiens | 1 | ALA2040739 | assay format | Scientific Literature | |
| 12. | ALA2044997 | B | Inhibition of human recombinant PDE7B-mediated [3H]cAMP hydrolysis at 10 uM after 20 mins by scintillation proximity assay | Homo sapiens | 1 | ALA2040739 | single protein format | Scientific Literature | |
| 13. | ALA2044998 | B | Inhibition of human recombinant PDE4B2 using fluorescein 3',5'-cyclic phosphate after 60 mins by IMAP fluorescence polarization assay | Homo sapiens | 1 | ALA2040739 | single protein format | Scientific Literature | |
| 14. | ALA2044999 | B | Inhibition of human recombinant PDE4D3 using fluorescein 3',5'-cyclic phosphate after 60 mins by IMAP fluorescence polarization assay | Homo sapiens | 1 | ALA2040739 | single protein format | Scientific Literature | |
| 15. | ALA2045000 | B | Inhibition of PDE7A1 in mouse RAW cells assessed as increase in cAMP level at 10 to 30 uM after 60 mins by enzyme immunoassay | Mus musculus | 2 | ALA2040739 | cell-based format | Scientific Literature | |
| 16. | ALA2045532 | A | Permeability across after 2 hrs 30 mins by pig brain lipid membrane based PAMPA-BBB assay | 1 | ALA2040739 | tissue-based format | Scientific Literature | ||
| 17. | ALA2045533 | F | Antiinflammatory activity in C57BL/6J mouse MOG(35 to 55)-induced experimental autoimmune encephalomyelitis model assessed as inhibition of clinical symptoms at 10 mg/kg, ip dosed daily for 16 days starting at day 5 after disease onset measured on day 32 post-immunization | Mus musculus | 1 | ALA2040739 | organism-based format | Scientific Literature | |
| 18. | ALA2045534 | F | Antiinflammatory activity in C57BL/6J mouse MOG(35 to 55)-induced experimental autoimmune encephalomyelitis model assessed as inhibition of clinical symptoms at 10 mg/kg, ip dosed daily for 26 days starting at day 5 after disease onset measured on day 42 post-immunization | Mus musculus | 1 | ALA2040739 | organism-based format | Scientific Literature | |
| 19. | ALA2045535 | T | Toxicity in in C57BL/6J mouse MOG(35 to 55)-induced experimental autoimmune encephalomyelitis model assessed as decrease in body weight at 10 mg/kg, ip dosed daily for 26 days starting at day 5 after disease onset measured on day 42 post-immunization | Mus musculus | 1 | ALA2040739 | organism-based format | Scientific Literature | |
| 20. | ALA3383887 | B | Inhibition of PDE7 (unknown origin) | Homo sapiens | 3 | ALA3352280 | protein format | Scientific Literature |
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