| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2050419 | B | Inhibition of human recombinant HDAC6 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescence analysis | Homo sapiens | 46 | single protein format | Scientific Literature | ||
| 2. | ALA2050420 | B | Inhibition of human recombinant HDAC1 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescence analysis | Homo sapiens | 46 | single protein format | Scientific Literature | ||
| 3. | ALA2050421 | B | Selectivity index, ratio of IC50 for human recombinant HDAC6 to IC50 for human recombinant HDAC1 | Homo sapiens | 37 | assay format | Scientific Literature | ||
| 4. | ALA2050422 | B | Inhibition of Bordetella sp. (strain FB188) N-terminus His-tagged HDAH expressed in Escherichia coli BL21 (DE3) up to 100 uM | Alcaligenaceae bacterium FB188 | 59 | assay format | Scientific Literature | ||
| 5. | ALA2050423 | B | Inhibition of Bordetella sp. (strain FB188) N-terminus His-tagged HDAH expressed in Escherichia coli BL21 (DE3) | Alcaligenaceae bacterium FB188 | 4 | assay format | Scientific Literature | ||
| 6. | ALA2050424 | B | Inhibition of human recombinant HDAC7 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescence analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 7. | ALA2050425 | B | Inhibition of human recombinant HDAC8 using Boc-lys(Ac)-AMC as substrate preincubated for 20 mins with substrate measured after 60 mins by fluorescence analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 8. | ALA2050429 | F | Growth inhibition of human A549 cells after 96 hrs by sulphorhodamine B assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 9. | ALA2050430 | F | Growth inhibition of human MCF7 cells after 96 hrs by sulphorhodamine B assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 10. | ALA2050431 | A | Growth inhibition of human WI38 cells after 96 hrs by sulphorhodamine B assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 11. | ALA2050435 | B | Inhibition of HDAC1 in human MCF7 cells assessed as up-regulation of acetylated histone H3 protein level at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA2050438 | B | Inhibition of Class 1 histone deacetylase in human MCF7 cells assessed as up-regulation of p21 protein level at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA2050441 | B | Inhibition of HDAC6 in human MCF7 cells assessed as change in tubulin acetylation level at 1 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA2050442 | B | Inhibition of HDAC6 in human MCF7 cells assessed as change in tubulin acetylation level at 0.5 uM after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4679516 | B | Inhibition of HDAC3 in human HL-60 cells assessed as increase in Ac-H3 level at 0.5 to 2 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4679523 | T | Toxicity in mouse LL/2 cells inoculated C57BL/6J mouse assessed as effect on body weight by measuring end body weight at 25 mg/kg, ip administered for 12 days and measured for every 2 days (Rvb = 18.1 +/- 0.2 g) | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 17. | ALA4679524 | T | Toxicity in mouse LL/2 cells inoculated C57BL/6J mouse assessed as effect on body weight by measuring initial body weight at 25 mg/kg, ip administered for 12 days measured for every 2 days (Rvb = 18.4 +/- 0.4 g) | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 18. | ALA4679525 | F | Antitumor activity against mouse LL/2 cells inoculated in C57BL/6J mouse assessed as tumor growth inhibition at 25 mg/kg, ip administered for 12 days | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 19. | ALA4679526 | F | Antitumor activity against mouse LL/2 cells inoculated in C57BL/6J mouse assessed as reduction of tumor weight at 25 mg/kg, ip administered for 12 days measured at day 14 (Rvb = 0.98 +/- 0.07 g) | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 20. | ALA4679527 | B | Inhibition of HDAC2 in human HL-60 cells assessed as increase in Ac-H3 level at 0.5 to 2 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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