# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2050595 | A | Metabolic stability of the compound in human serum at 0.5 mM after 3 hrs by RP-HPLC analysis | Homo sapiens | 6 | cell-free format | Scientific Literature | ||
2. | ALA2050596 | P | Binding affinity to Cu2+ assessed as formation of compound-cu2+ complex formation by pH-metric technique | 4 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA2050597 | P | Lipophilicity, log D of the compound at pH 7.4 by shake-flask method | 5 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA2050598 | F | Antioxidant activity against CuSO4-induced LDL oxidation assessed as delta-lag time at 100 uM by spectrophotometric analysis | 5 | assay format | Scientific Literature | |||
5. | ALA2050599 | F | Antioxidant activity against CuSO4-induced LDL oxidation measured per mg of LDL product assessed as propagation rate of the oxidation at 100 uM by spectrophotometric analysis | 5 | assay format | Scientific Literature | |||
6. | ALA2050600 | F | Antioxidant activity assessed as (E)-4-hydroxy-trans-2,3-nonenal scavenging activity in phosphate buffer at pH 7.4 at 1 mM after 24 hrs by reverse-phase HPLC analysis relative to control | 5 | assay format | Scientific Literature | |||
7. | ALA2050601 | F | Vasodilator activity in Wistar rat endothelium-denuded thoracic aorta assessed as inhibition of L-phenylephrine-induced contraction | Rattus norvegicus | 7 | tissue-based format | Scientific Literature | ||
8. | ALA2050602 | F | Vasodilator activity in Wistar rat endothelium-denuded thoracic aorta assessed as inhibition of L-phenylephrine-induced contraction in presence of ODQ | Rattus norvegicus | 4 | tissue-based format | Scientific Literature | ||
9. | ALA2049865 | F | Protection against hypoxia-induced brain damage in Wistar rat ischemia-reperfusion injury model assessed as reduction of cerebral infarct volume at 500 mg/kg, iv administered at beginning of reperfusion and again after 6 hrs measured 24 hrs after reperfusion | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
10. | ALA2049867 | F | Reduction of ischemia-reperfusion-induced TNFalpha level increase in Wistar rat serum at 500 mg/kg, iv by ELISA | Rattus norvegicus | 2 | organism-based format | Scientific Literature |