# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2049885 | F | Antimicrobial activity against Staphylococcus aureus | Staphylococcus aureus | 18 | organism-based format | Scientific Literature | ||
2. | ALA2049886 | F | Antimicrobial activity against Corynebacterium diphtheriae | Corynebacterium diphtheriae | 19 | organism-based format | Scientific Literature | ||
3. | ALA2049887 | F | Antimicrobial activity against Klebsiella pneumoniae | Klebsiella pneumoniae | 21 | organism-based format | Scientific Literature | ||
4. | ALA2049888 | F | Antimicrobial activity against Escherichia coli | Escherichia coli | 21 | organism-based format | Scientific Literature | ||
5. | ALA2049889 | F | Antimicrobial activity against Aspergillus niger | Aspergillus niger | 17 | organism-based format | Scientific Literature | ||
6. | ALA2049890 | F | Antimicrobial activity against Candida albicans | Candida albicans | 18 | organism-based format | Scientific Literature | ||
7. | ALA3390766 | F | Antipyroptotic activity in PMA-differentiated and LPS-primed human THP1 cells assessed as decrease in ATP-induced pyroptosis measured as LDH activity at 10 uM after 1 hrs by colorimetric assay | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
8. | ALA3390767 | A | Cytotoxicity against human HK2 cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
9. | ALA4015418 | U | Cysteamine reactivity of the compound in PBS assessed as second order rate constant for free cysteamine release at 250 uM and pH 7.4 after 90 mins by DTNB reagent based RP-UHPLC analysis | 15 | assay format | Scientific Literature | |||
10. | ALA4015424 | A | Cytotoxicity against human THP1 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
11. | ALA4015426 | B | Inhibition of recombinant human NLRP3 ATPase assessed as hydrolysis of ATP at 100 uM preincubated for 15 mins followed by addition of ATP measured after 40 mins by ADP-Glo assay | Homo sapiens | 16 | single protein format | Scientific Literature | ||
12. | ALA4015427 | B | Inhibition of recombinant human NLRP3 ATPase assessed as hydrolysis of ATP at 50 uM preincubated for 15 mins followed by addition of ATP measured after 40 mins by ADP-Glo assay | Homo sapiens | 16 | single protein format | Scientific Literature | ||
13. | ALA4015428 | B | Inhibition of NLRP3 in PMA-differentiated and LPS-primed human THP1 cells assessed as decrease in ATP-induced pyroptosis measured as LDH activity at 10 uM preincubated for 1 hr followed by ATP addition measured after 1 hr by colorimetric assay relative to control | Homo sapiens | 13 | assay format | Scientific Literature | ||
14. | ALA4015486 | B | Inhibition of recombinant human NLRP3 ATPase assessed as hydrolysis of ATP preincubated for 15 mins followed by addition of ATP measured after 40 mins by ADP-Glo assay | Homo sapiens | 10 | single protein format | Scientific Literature |