# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2051012 | Functional | Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-glucosaminide method | Homo sapiens | 23 | ALA2046303 | cell-based format | Scientific Literature | |
2. | ALA2051013 | Functional | Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-glucosaminide method in presence of 10% human serum | Homo sapiens | 19 | ALA2046303 | cell-based format | Scientific Literature | |
3. | ALA2051014 | ADME | Metabolic stability in human liver microsomes assessed as compound remaining after 30 mins | Homo sapiens | 9 | ALA2046303 | microsome format | Scientific Literature | |
4. | ALA2051015 | ADME | Metabolic stability in rat liver microsomes assessed as compound remaining after 30 mins | Rattus norvegicus | 8 | ALA2046303 | microsome format | Scientific Literature | |
5. | ALA2051016 | ADME | Half life in Sprague-Dawley rat at 5 mg/kg, iv | Rattus norvegicus | 8 | ALA2046303 | organism-based format | Scientific Literature | |
6. | ALA2051017 | ADME | Clearance in Sprague-Dawley rat at 5 mg/kg, iv | Rattus norvegicus | 8 | ALA2046303 | organism-based format | Scientific Literature | |
7. | ALA2051018 | ADME | AUC in Sprague-Dawley rat at 5 mg/kg, iv | Rattus norvegicus | 8 | ALA2046303 | organism-based format | Scientific Literature | |
8. | ALA2051019 | Binding | Inhibition of human recombinant ICAM-1 adhesion into human Jurkat cells after 1 hr | Homo sapiens | 1 | ALA2046303 | cell-based format | Scientific Literature | |
9. | ALA2051020 | Toxicity | Genotoxicity in Salmonella typhimurium by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | ALA2046303 | organism-based format | Scientific Literature | |
10. | ALA2051021 | ADME | Inhibition of CYP3A4 | 1 | ALA2046303 | single protein format | Scientific Literature | ||
11. | ALA2051022 | ADME | Inhibition of CYP2C9 | 1 | ALA2046303 | single protein format | Scientific Literature | ||
12. | ALA2051023 | Binding | Inhibition of human ERG | Homo sapiens | 1 | ALA2046303 | single protein format | Scientific Literature | |
13. | ALA2051031 | Toxicity | Toxicity in dog administered topically with 1% PBS solution tid for 12 weeks | Canis lupus familiaris | 1 | ALA2046303 | organism-based format | Scientific Literature | |
14. | ALA2051032 | Functional | Increase of mean schirmer's tear test in dog administered topically with 1% PBS solution tid for 12 weeks measured after 1 to 12 weeks | Canis lupus familiaris | 1 | ALA2046303 | organism-based format | Scientific Literature | |
15. | ALA2051033 | Binding | Inhibition of ICAM-1-mediated IFNgamma release | 1 | ALA2046303 | single protein format | Scientific Literature | ||
16. | ALA2051034 | Binding | Inhibition of ICAM-1-mediated MIP-1alpha release | 1 | ALA2046303 | single protein format | Scientific Literature | ||
17. | ALA2051138 | Binding | Inhibition of ICAM-1-mediated IL-1alpha release | 1 | ALA2046303 | single protein format | Scientific Literature | ||
18. | ALA2051139 | Binding | Inhibition of ICAM-1-mediated IL-1beta release | 1 | ALA2046303 | single protein format | Scientific Literature | ||
19. | ALA2051140 | Binding | Inhibition of ICAM-1-mediated IL-6 release | 1 | ALA2046303 | single protein format | Scientific Literature | ||
20. | ALA2051141 | Binding | Inhibition of ICAM-1-mediated IL-10 release | 1 | ALA2046303 | single protein format | Scientific Literature |