| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2060493 | B | Inhibition of human dUTPase assessed as production of [5-3H]dUMP from [5-3H]dUTP after 15 mins measured by HPLC analysis | Homo sapiens | 20 | ALA2057196 | single protein format | Scientific Literature | |
| 2. | ALA2060494 | F | Potentiation of antiproliferative activity of FdUrd against human HeLaS3 cells assessed as compound concentration causing 50% reduction in 1 uM FdUrd T/C value after 24 hrs by crystal violet assay | Homo sapiens | 14 | ALA2057196 | cell-based format | Scientific Literature | |
| 3. | ALA2060496 | A | AUCt in Balb/c-A mouse at 50 mg/kg, po in a solution containing 2.5% DMA, 2.5% Tween 80 and 10% cremophor EL | Mus musculus | 1 | ALA2057196 | organism-based format | Scientific Literature | |
| 4. | ALA2060497 | A | Cmax in Balb/c-A mouse at 50 mg/kg, po in a solution containing 2.5% DMA, 2.5% Tween 80 and 10% cremophor EL | Mus musculus | 1 | ALA2057196 | organism-based format | Scientific Literature | |
| 5. | ALA2060498 | A | Half life in Balb/c-A mouse at 50 mg/kg, po in a solution containing 2.5% DMA, 2.5% Tween 80 and 10% cremophor EL | Mus musculus | 1 | ALA2057196 | organism-based format | Scientific Literature | |
| 6. | ALA2060499 | A | Tmax in Balb/c-A mouse at 50 mg/kg, po in a solution containing 2.5% DMA, 2.5% Tween 80 and 10% cremophor EL | Mus musculus | 1 | ALA2057196 | organism-based format | Scientific Literature | |
| 7. | ALA2060503 | F | Antitumor activity against human MX1 cells xenografted in Balb/c-A JcL-nu mouse assessed as tumor volume at 300 mg/kg/day, po for 14 days measured on day 15 (Rvb = 2048 +/- 693.7 mm3) | Homo sapiens | 1 | ALA2057196 | organism-based format | Scientific Literature | |
| 8. | ALA2060504 | F | Antitumor activity against human MX1 cells xenografted in Balb/c-A JcL-nu mouse assessed as decrease in tumor volume at 300 mg/kg/day, po for 14 days measured on day 15 relative to control (Rvb = 11.4 +/- 3.74) | Homo sapiens | 1 | ALA2057196 | organism-based format | Scientific Literature | |
| 9. | ALA2060505 | F | Antitumor activity against human MX1 cells xenografted in Balb/c-A JcL-nu mouse assessed as tumor growth inhibition at 300 mg/kg/day, po for 14 days measured on day 15 relative to control | Homo sapiens | 1 | ALA2057196 | organism-based format | Scientific Literature | |
| 10. | ALA2060506 | F | Potentiation of antitumor activity of 5-Fu against human MX1 cells xenografted in Balb/c-A JcL-nu mouse assessed as tumor volume at 300 mg/kg/day, po for 14 days measured on day 15 (Rvb = 2048 +/- 693.7 mm3) | Homo sapiens | 1 | ALA2057196 | organism-based format | Scientific Literature | |
| 11. | ALA2060507 | F | Potentiation of antitumor activity of 5-Fu against human MX1 cells xenografted in Balb/c-A JcL-nu mouse assessed as decrease in tumor volume at 300 mg/kg/day, po for 14 days measured on day 15 relative to control (Rvb = 11.4 +/- 3.74) | Homo sapiens | 1 | ALA2057196 | organism-based format | Scientific Literature | |
| 12. | ALA2060508 | F | Potentiation of antitumor activity of 5-Fu against human MX1 cells xenografted in Balb/c-A JcL-nu mouse assessed as tumor growth inhibition at 300 mg/kg/day, po for 14 days measured on day 15 relative to control | Homo sapiens | 1 | ALA2057196 | organism-based format | Scientific Literature | |
| 13. | ALA2060509 | T | Toxicity in Balb/c-A JcL-nu mouse bearing human MX1 cells assessed as decrease in body weight at 300 mg/kg/day, po administered for 15 days and co-treated with 5-Fu | Mus musculus | 1 | ALA2057196 | organism-based format | Scientific Literature | |
| 14. | ALA2060511 | F | Antiproliferative activity against human HeLaS3 cells after 24 hrs by crystal violet assay | Homo sapiens | 1 | ALA2057196 | cell-based format | Scientific Literature | |
| 15. | ALA3705334 | B | Inhibition Assay: The inhibitory activity of the compound against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate from [5-3H]deoxyuridine triphosphate. | Homo sapiens | 141 | ALA3638618 | single protein format | BindingDB Database | |
| 16. | ALA3705505 | B | Inhibition Assay: The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyuridine monophosphate (hereinafter, referred to as [5-3H]dUMP) from [5-3H]deoxyuridine triphosphate (hereinafter, referred to as [5-3H]dUTP) according to a method shown below.Specifically, 0.2 mL in total of a solution containing 0.02 mL of 1 uM dUTP (including 588 Bq/mL [5-3H]dUTP), 0.05 mL of a 0.2 M Tris buffer solution (pH 7.4), 0.05 mL of 16 mM magnesium chloride, 0.02 mL of 20 mM 2-mercaptoethanol, 0.02 mL of a 1% aqueous solution of fetal bovine serum-derived albumin, 0.02 mL of varying concentrations of test compound solutions or pure water as a control, and 0.02 mL of a solution of human dUTPase, which is expressed in E. coli and then purified, was incubated at 37 C. for 15 minutes. After the incubation, the solution was heated at 100 C. for 1 minute to terminate the reaction, followed by centrifugation at 15000 rpm for 2 minutes. | Homo sapiens | 20 | ALA3639332 | assay format | BindingDB Database |
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