| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2060405 | B | Displacement of [3H]paraiodoclonidine from imidazoline I1 receptor in rat PC12 cells after 30 mins by gamma counter | Rattus norvegicus | 7 | cell-based format | Scientific Literature | ||
| 2. | ALA2060406 | B | Displacement of [3H]idazoxan from imidazoline I2 receptor in New Zealand rabbit renal cortex homogenate after 60 mins by gamma counter | Oryctolagus cuniculus | 7 | assay format | Scientific Literature | ||
| 3. | ALA2060407 | B | Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 4. | ALA2060408 | B | Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 5. | ALA2060409 | B | Displacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counter | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 6. | ALA2060410 | B | Selectivity ratio of compound to clonidine for human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counter | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA2060411 | B | Selectivity ratio of compound to clonidine for human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counter | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA2060412 | B | Selectivity ratio of compound to clonidine for human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counter | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA2060421 | F | Hypotensive activity in spontaneous hypertensive rat assessed as decrease in mean blood pressure at 1 mg/kg, iv measured after 5 mins relative to control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA2060423 | T | Toxicity in spontaneous hypertensive rat assessed as vasoconstrictive activity at 1 mg/kg, iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA3301366 | A | ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole rat plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. | Rattus norvegicus | 717 | cell-free format | AstraZeneca Deposited Data | ||
| 12. | ALA3301372 | A | ASTRAZENECA: Intrinsic clearance measured in human hepatocytes following incubation at 37C. Experimental range <3 to >150 microL/min/1E6 cells. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736. | Homo sapiens | 408 | cell-based format | AstraZeneca Deposited Data | ||
| 13. | ALA3411418 | B | Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma counting | Rattus norvegicus | 27 | cell-based format | Scientific Literature | ||
| 14. | ALA3411419 | B | Displacement of [3H]RX821002 from human alpha2 adrenoceptor expressed in CHO cell membranes after 60 mins | Homo sapiens | 27 | cell-based format | Scientific Literature |
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