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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA2061994 B Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assay Homo sapiens 25 cell-based format Scientific Literature 2. ALA2060771 B Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis Homo sapiens 20 cell-based format Scientific Literature 3. ALA2060772 B Inhibition of p38alpha Homo sapiens 24 single protein format Scientific Literature 4. ALA2060773 P Aqueous solubility of the compound at pH 7.4 25 small-molecule physicochemical format Scientific Literature 5. ALA2060774 A Fraction unbound in human plasma Homo sapiens 25 cell-free format Scientific Literature 6. ALA2060775 A Clearance in CD-1 mouse at 3 mg/kg, iv and 10 mg/kg, po Mus musculus 2 organism-based format Scientific Literature 7. ALA2060776 A Volume of distribution at steady state in CD-1 mouse at 3 mg/kg, iv and 10 mg/kg, po Mus musculus 2 organism-based format Scientific Literature 8. ALA2060777 A AUC in CD-1 mouse at 10 mg/kg, po Mus musculus 2 organism-based format Scientific Literature 9. ALA2060778 A Half life in CD-1 mouse at 3 mg/kg, iv Mus musculus 2 organism-based format Scientific Literature 10. ALA2060779 A Oral bioavailability in CD-1 mouse at 10 mg/kg Mus musculus 2 organism-based format Scientific Literature 11. ALA3301363 P ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 4,197 small-molecule physicochemical format AstraZeneca Deposited Data 12. ALA3301365 A ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with whole human plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. Homo sapiens 1,614 cell-free format AstraZeneca Deposited Data