# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2073525 | B | Inhibition of IKKbeta using 5FAM-GRHDSGLDSMK-NH2 as substrate incubated for 10 mins prior to substrate addition by IMAP-TR-FRET assay | Homo sapiens | 19 | ALA2069238 | single protein format | Scientific Literature | |
2. | ALA2073526 | B | Inhibition of IKKbeta in human HeLa cells assessed as inhibition of TPA-induced NFkappaB activation at 10 uM incubated for 1 hr prior to TPA-challenge measured after 8 hrs by luciferase reporter gene assay | Homo sapiens | 15 | ALA2069238 | cell-based format | Scientific Literature | |
3. | ALA2073527 | B | Inhibition of IKKbeta in mouse CIA model splenocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA | Mus musculus | 14 | ALA2069238 | cell-based format | Scientific Literature | |
4. | ALA2073528 | B | Inhibition of IKKalpha | Homo sapiens | 4 | ALA2069238 | single protein format | Scientific Literature | |
5. | ALA2073529 | B | Inhibition of MAPK p38alpha | Homo sapiens | 3 | ALA2069238 | single protein format | Scientific Literature | |
6. | ALA2073530 | B | Inhibition of MAPK p38beta | Homo sapiens | 3 | ALA2069238 | single protein format | Scientific Literature | |
7. | ALA2073531 | B | Inhibition of JNK1 | Homo sapiens | 3 | ALA2069238 | single protein format | Scientific Literature | |
8. | ALA2073532 | B | Inhibition of JNK2 | Homo sapiens | 3 | ALA2069238 | single protein format | Scientific Literature | |
9. | ALA2073533 | B | Inhibition of JNK3 | Homo sapiens | 3 | ALA2069238 | single protein format | Scientific Literature | |
10. | ALA2073534 | B | Selectivity ratio of IC50 for IKKalpha to IC50 for IKKbeta | Homo sapiens | 3 | ALA2069238 | assay format | Scientific Literature | |
11. | ALA2073535 | B | Inhibition of IKKbeta using 5FAM-GRHDSGLDSMK-NH2 as substrate at 10 uM incubated for 10 mins prior to substrate addition by IMAP-TR-FRET assay | Homo sapiens | 31 | ALA2069238 | single protein format | Scientific Literature | |
12. | ALA3767148 | B | Inhibition of IKKbeta (unknown origin) at 10 uM by TR-FRET assay | Homo sapiens | 17 | ALA3763027 | single protein format | Scientific Literature | |
13. | ALA3767149 | B | Inhibition of IKKbeta (unknown origin) by TR-FRET assay | Homo sapiens | 15 | ALA3763027 | single protein format | Scientific Literature | |
14. | ALA3767150 | B | Inhibition of IKKbeta (unknown origin) transfected in human HeLa cells assessed as inhibition of TPA-induced NF-kappaB activation at 10 uM pre-incubated with compound for 1 hr followed by TPA addition after 8 hrs by luciferase reporter gene assay | Homo sapiens | 13 | ALA3763027 | cell-based format | Scientific Literature | |
15. | ALA3767151 | B | Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by ELISA | Mus musculus | 13 | ALA3763027 | assay format | Scientific Literature | |
16. | ALA3767152 | A | Metabolic stability in rat plasma assessed as compound remaining after 120 mins | Rattus norvegicus | 8 | ALA3763027 | cell-free format | Scientific Literature | |
17. | ALA3767153 | A | Half life in human microsomes | Homo sapiens | 8 | ALA3763027 | assay format | Scientific Literature |