# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2091472 | F | Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for 10 mins by FLIPR assay | Rattus norvegicus | 30 | ALA2086339 | cell-based format | Scientific Literature | |
2. | ALA2091473 | F | Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for 10 mins by FLIPR assay relative to nicotine | Rattus norvegicus | 30 | ALA2086339 | cell-based format | Scientific Literature | |
3. | ALA2091474 | F | Antagonist activity at alpha1beta1deltagamma receptor in human TE671 cells assessed as inhibition of epibatidine-induced membrane potential measured every 1 sec for 1 min followed by every 3 secs for 3 mins by FLIPR assay | Homo sapiens | 9 | ALA2086339 | cell-based format | Scientific Literature | |
4. | ALA2091475 | F | Antagonist activity at human alpha3 receptor in SH-SY5Y cells assessed as inhibition of epibatidine-induced membrane potential measured every 1 sec for 1 min followed by every 3 secs for 3 mins by FLIPR assay | Homo sapiens | 9 | ALA2086339 | cell-based format | Scientific Literature | |
5. | ALA2091623 | F | Antagonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as inhibition of m-chlorophenylbiguanide-induced calcium influx measured every 1 sec for 1 min followed by every 3 secs for 3 mins by FLIPR assay | Homo sapiens | 9 | ALA2086339 | cell-based format | Scientific Literature | |
6. | ALA2091624 | P | Solubility of the compound at pseudo-thermodynamic equilibrium after 24 hrs by UPLC/UV/TOF-MS analysis at pH 7.4 | 22 | ALA2086339 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA2091625 | A | Permeability of the compound at 10 uM after 4 hrs by PAMPA assay | 22 | ALA2086339 | assay format | Scientific Literature | ||
8. | ALA2091626 | A | Induction of human CYP3A4-mediated metabolism assessed as compound remaining at 1 uM after 1 hr | Homo sapiens | 22 | ALA2086339 | single protein format | Scientific Literature | |
9. | ALA2091627 | A | Inhibition of CYP3A4 using BFC as substrate at 3 uM after 30 mins by Gentest method | 22 | ALA2086339 | single protein format | Scientific Literature | ||
10. | ALA2091628 | A | Inhibition of CYP2D6 using AMMC as substrate at 3 uM after 30 mins by Gentest method | 22 | ALA2086339 | single protein format | Scientific Literature | ||
11. | ALA2091629 | A | Inhibition of CYP2C9 using MFC as substrate at 3 uM after 45 mins by Gentest method | 22 | ALA2086339 | single protein format | Scientific Literature | ||
12. | ALA2091636 | A | Metabolic stability in rat plasma assessed as compound remaining at 250 uM after 3 hrs by LC-ESI-MS-MS analysis | Rattus norvegicus | 2 | ALA2086339 | cell-free format | Scientific Literature | |
13. | ALA2091652 | F | Agonist activity at alpha1beta1deltagamma receptor in human TE671 cells by FLIPR assay | Homo sapiens | 28 | ALA2086339 | cell-based format | Scientific Literature | |
14. | ALA2091653 | F | Agonist activity at human alpha3 receptor in SH-SY5Y cells | Homo sapiens | 28 | ALA2086339 | cell-based format | Scientific Literature | |
15. | ALA2091654 | F | Antagonist activity at human 5HT3A receptor expressed in HEK293 cells | Homo sapiens | 28 | ALA2086339 | cell-based format | Scientific Literature |