| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2092208 | B | Inhibition of human His6-tagged recombinant FPPS expressed in Escherichia coli BL21(DE3) using GPP and [3H]IPP as substrate incubated for 5 mins prior to substrate addition measured after 20 mins by liquid scintillation counting | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 2. | ALA2092209 | B | Inhibition of human N-terminal His6-tagged recombinant human GGPS expressed in Escherichia coli BL21(DE3) using FPP and [14C]IPP as substrate at 10 uM by scintillation counting | Homo sapiens | 17 | assay format | Scientific Literature | ||
| 3. | ALA3091231 | B | Ratio of IC50 for human recombinant FPPS incubated for 10 mins prior to substrate addition by scintillation counting analysis to IC50 for human recombinant FPPS incubated for 10 mins prior to substrate addition measured after 8 mins by scintillation counting analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 4. | ALA3091234 | B | Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate up to 10 uM incubated for 10 mins prior to substrate addition measured after 8 mins by scintillation counting analysis | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 5. | ALA3091236 | B | Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate incubated for 10 mins prior to substrate addition measured after 8 mins by scintillation counting analysis | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 6. | ALA3091237 | B | Inhibition of human recombinant FPPS using GPP/[3H]IPP as substrate incubated for 10 mins prior to substrate addition by scintillation counting analysis | Homo sapiens | 11 | single protein format | Scientific Literature | ||
| 7. | ALA3369319 | B | Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by liquid scintillation counting analysis | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 8. | ALA3369326 | B | Inhibition of FPPS in human SH-SY5Y cells assessed as blocking of tau metabolism by measuring ratio of tau phosphorylation to total tau level at 100 nM after 24 hrs by ELISA (Rvb = 0.012 no-unit) | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 9. | ALA3369327 | A | Cytotoxicity against human SH-SY5Y cells assessed as LDH release after 48 hrs (Rvb = 0%) | Homo sapiens | 14 | cell-based format | Scientific Literature |
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