#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA2089691	Binding	Inhibition of human CDK4/cyclin D1 expressed in baculovirus infected Sf9 cells assessed as inhibition of pRb Ser780 phosphorylation after 60 mins by TR-FRET assay	Homo sapiens	6	ALA2086364	cell-based format	Scientific Literature
2.	ALA2089692	Binding	Inhibition of human CDK6/cyclin D3 assessed as inhibition of pRb Ser780 phosphorylation after 120 mins by TR-FRET assay	Homo sapiens	4	ALA2086364	protein complex format	Scientific Literature
3.	ALA2089695	Binding	Inhibition of human CDK1/cyclin B assessed as inhibition of Tamra-H1 phosphorylation by IMAP-FP assay	Homo sapiens	6	ALA2086364	protein complex format	Scientific Literature
4.	ALA2089696	Binding	Inhibition of human CDK2/cyclin A assessed as inhibition of Tamra-H1 phosphorylation by IMAP-FP assay	Homo sapiens	6	ALA2086364	protein complex format	Scientific Literature
5.	ALA2089698	Binding	Selectivity ratio of IC50 for human CDK4/cyclin D1 over IC50 for human CDK1/cyclin B	Homo sapiens	2	ALA2086364	assay format	Scientific Literature
6.	ALA2089700	Binding	Selectivity ratio of IC50 for human CDK4/cyclin D1 over IC50 for human CDK2/cyclin A	Homo sapiens	2	ALA2086364	assay format	Scientific Literature
7.	ALA2089702	ADME	AUC (0 to 8 hrs) in Sprague-Dawley rat at 5 mg/kg, po	Rattus norvegicus	3	ALA2086364	organism-based format	Scientific Literature
8.	ALA2089703	ADME	Oral bioavailability in Sprague-Dawley rat at 5 mg/kg	Rattus norvegicus	1	ALA2086364	organism-based format	Scientific Literature
9.	ALA2089704	ADME	Plasma clearance in Sprague-Dawley rat at 1 mg/kg, iv	Rattus norvegicus	1	ALA2086364	organism-based format	Scientific Literature
10.	ALA2089705	Binding	Inhibition of CDK4/CDK6 assessed as pRb phosphorylation in human JeKo1 cells by immunoblotting	Homo sapiens	1	ALA2086364	cell-based format	Scientific Literature
11.	ALA2089706	Functional	Cell cycle arrest in human JeKo1 cells assessed as accumulation at G1 phase by PI-based FACS analysis	Homo sapiens	1	ALA2086364	cell-based format	Scientific Literature
12.	ALA2089796	Functional	Cell cycle arrest in human JeKo1 cells assessed as accumulation at G1 phase at 0.625 to 2.5 uM by PI-based FACS analysis	Homo sapiens	1	ALA2086364	cell-based format	Scientific Literature
13.	ALA2089797	Functional	Cell cycle arrest in human JeKo1 cells assessed as accumulation at G2 phase at 10 uM by PI-based FACS analysis	Homo sapiens	1	ALA2086364	cell-based format	Scientific Literature
14.	ALA2089798	Functional	Cell cycle arrest in human JeKo1 cells assessed as accumulation at S phase at 10 uM by PI-based FACS analysis	Homo sapiens	1	ALA2086364	cell-based format	Scientific Literature
15.	ALA2089799	Functional	Inhibition of CDK4/6 in human JeKo1 cells xenografted po dosed SCID beige mouse assessed as reduction of pRb phosphorylation administered BID for 2.5 days by ELISA	Mus musculus	1	ALA2086364	organism-based format	Scientific Literature
16.	ALA2089800	Functional	Inhibition of CDK4/6 in human JeKo1 cells xenografted SCID beige mouse assessed as reduction of pRb phosphorylation at 250 mg/kg/day administered BID for 2.5 days post-last dose by ELISA relative to vehicle-treated control	Mus musculus	1	ALA2086364	organism-based format	Scientific Literature
17.	ALA2089801	Functional	Inhibition of CDK4/6 in human JeKo1 cells xenografted in SCID beige mouse assessed as reduction of pRb phosphorylation at 250 mg/kg/day administered BID for 2.5 days measured after 7 hrs post-last dose by ELISA relative to vehicle-treated control	Mus musculus	1	ALA2086364	organism-based format	Scientific Literature
18.	ALA2089802	Functional	Inhibition of CDK4/6 in human JeKo1 cells xenografted in SCID beige mouse assessed as reduction of pRb phosphorylation at 500 mg/kg/day administered BID for 2.5 days measured after 1 hr post-last dose by ELISA relative to vehicle-treated control	Mus musculus	1	ALA2086364	organism-based format	Scientific Literature
19.	ALA2089803	Functional	Inhibition of CDK4/6 in human JeKo1 cells xenografted in SCID beige mouse assessed as reduction of pRb phosphorylation at 500 mg/kg/day administered BID for 2.5 days measured after 7 hrs post-last dose by ELISA relative to vehicle-treated control	Mus musculus	1	ALA2086364	organism-based format	Scientific Literature
20.	ALA2089804	Toxicity	Toxicity in po dosed SCID beige mouse administered BID	Mus musculus	1	ALA2086364	organism-based format	Scientific Literature