| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4182004 | B | Inhibition of SERT in rat brain synaptosomes assessed as reduction in [3H]-5-HT uptake measured after 15 mins by scintillation counting method | Rattus norvegicus | 7 | subcellular format | Scientific Literature | ||
| 2. | ALA4182005 | B | Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA4182006 | B | Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA4182007 | A | Half-life in rat liver microsomes at 1 uM in presence of NADPH regenerating system by LC-MS/MS analysis | Rattus norvegicus | 4 | microsome format | Scientific Literature | ||
| 5. | ALA4182008 | A | Clearance in rat liver microsomes at 1 uM measured after 90 mins in presence of NADPH regenerating system by LC-MS/MS analysis | Rattus norvegicus | 4 | microsome format | Scientific Literature | ||
| 6. | ALA4182009 | F | Antidepressant-like activity in mouse assessed as reduction in immobility time at 20 mg/kg, po administered once daily for 7 days measured last 4 mins of 6 mins test by forced swim test relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA4254543 | B | Inhibition of [3H]serotonin reuptake in rat brain synaptosomes SERT after 15 mins by TopCount scintillation counting method | Rattus norvegicus | 17 | subcellular format | Scientific Literature | ||
| 8. | ALA4254545 | B | Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes after 60 mins by TopCount scintillation counting method | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 9. | ALA4254547 | B | Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 10. | ALA4254548 | A | Half life in rat liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 11 | microsome format | Scientific Literature | ||
| 11. | ALA4254549 | A | Clearance in rat liver microsomes at 1 uM in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 11 | microsome format | Scientific Literature | ||
| 12. | ALA4254550 | F | Antidepressant-like activity in mouse assessed as reduction in immobility time at 40 mg/kg/day, po once daily for 7 days measured for last 4 mins of 6 mins test at 1 hr post last dose by forced swim test relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA4303810 | F | Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HRCE cells at MOI 0.4 after 96 hrs (reported as hit score from 0-1 for on-disease vs off-disease activity: scores >0.6 considered hits) | Homo sapiens | 1,629 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | ||
| 14. | ALA4409660 | B | Displacement of [3H]-8-OH-DPAT from 5HT1A receptor (unknown origin) expressed in HEK293 cells membranes incubated for 60 mins by scintillation counting method | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 15. | ALA4409662 | B | Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 16. | ALA4409664 | B | Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting method | Rattus norvegicus | 13 | subcellular format | Scientific Literature | ||
| 17. | ALA4409666 | A | Half life in rat liver microsomes at 1 uM in presence of NADPH generating system measured for 10 to 90 mins by LC-MS/MS analysis | Rattus norvegicus | 15 | microsome format | Scientific Literature | ||
| 18. | ALA4409667 | A | Clearance in rat liver microsomes at 1 uM in presence of NADPH generating system measured for 10 to 90 mins by LC-MS/MS analysis | Rattus norvegicus | 15 | microsome format | Scientific Literature | ||
| 19. | ALA4409668 | A | Half life in human liver microsomes at 1 uM in presence of NADPH generating system measured for 10 to 90 mins by LC-MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 20. | ALA4409669 | A | Clearance in human liver microsomes at 1 uM in presence of NADPH generating system measured for 10 to 90 mins by LC-MS/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature |
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