# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3540946 | ADME | Drug metabolism in rat urine assessed as N-((4-(4-fluorophenyl)-2-oxochroman-7-yl)methyl)-2-((S)-2-hydroxy-2-(trifluoromethyl)butanoyl)hydrazinecarboxamide level | Rattus norvegicus | 1 | ALA3526019 | tissue-based format | Scientific Literature | |
2. | ALA3530293 | ADME | Activity of rat recombinant CYP1A1 expressed in baculovirus-infected insect cells assessed as enzyme-mediated N-((4-(4-fluorophenyl)-2-oxochroman-7-yl)methyl)-2-((S)-2-hydroxy-2-(trifluoromethyl)butanoyl)hydrazinecarboxamide formation at 10 uM preincubated for 3 mins measured after 30 mins in presence of 1 mM NADPH | Rattus norvegicus | 1 | ALA3526019 | cell-based format | Scientific Literature | |
3. | ALA3530294 | ADME | Activity of rat recombinant CYP1A2 expressed in baculovirus-infected insect cells assessed as enzyme-mediated N-((4-(4-fluorophenyl)-2-oxochroman-7-yl)methyl)-2-((S)-2-hydroxy-2-(trifluoromethyl)butanoyl)hydrazinecarboxamide formation at 10 uM preincubated for 3 mins measured after 30 mins in presence of 1 mM NADPH | Rattus norvegicus | 1 | ALA3526019 | cell-based format | Scientific Literature | |
4. | ALA3530295 | ADME | Activity of rat recombinant CYP3A1 expressed in baculovirus-infected insect cells assessed as enzyme-mediated N-((4-(4-fluorophenyl)-2-oxochroman-7-yl)methyl)-2-((S)-2-hydroxy-2-(trifluoromethyl)butanoyl)hydrazinecarboxamide formation at 10 uM preincubated for 3 mins measured after 30 mins in presence of 1 mM NADPH | Rattus norvegicus | 1 | ALA3526019 | cell-based format | Scientific Literature | |
5. | ALA3530296 | ADME | Activity of rat recombinant CYP3A2 expressed in baculovirus-infected insect cells assessed as enzyme-mediated N-((4-(4-fluorophenyl)-2-oxochroman-7-yl)methyl)-2-((S)-2-hydroxy-2-(trifluoromethyl)butanoyl)hydrazinecarboxamide formation at 10 uM preincubated for 3 mins measured after 30 mins in presence of 1 mM NADPH | Rattus norvegicus | 1 | ALA3526019 | cell-based format | Scientific Literature | |
6. | ALA3530301 | ADME | Drug metabolism in rat liver microsomes assessed as N-((4-(4-fluorophenyl)-2-oxochroman-7-yl)methyl)-2-((S)-2-hydroxy-2-(trifluoromethyl)butanoyl)hydrazinecarboxamide formation by Michaelis-Menten equation in presence of 1 mM NADPH for 10 mins | Rattus norvegicus | 1 | ALA3526019 | assay format | Scientific Literature | |
7. | ALA3530302 | ADME | Activity of rat recombinant CYP1A1 expressed in baculovirus-infected insect cells assessed as enzyme-mediated N-((4-(4-fluorophenyl)-2-oxochroman-7-yl)methyl)-2-((S)-2-hydroxy-2-(trifluoromethyl)butanoyl)hydrazinecarboxamide formation preincubated for 3 mins by Michaelis-Menten equation in presence of NADPH for 10 mins | Rattus norvegicus | 1 | ALA3526019 | cell-based format | Scientific Literature | |
8. | ALA3530303 | ADME | Activity of rat recombinant CYP1A2 expressed in baculovirus-infected insect cells assessed as enzyme-mediated N-((4-(4-fluorophenyl)-2-oxochroman-7-yl)methyl)-2-((S)-2-hydroxy-2-(trifluoromethyl)butanoyl)hydrazinecarboxamide formation preincubated for 3 mins by Michaelis-Menten equation in presence of NADPH for 10 mins | Rattus norvegicus | 1 | ALA3526019 | cell-based format | Scientific Literature | |
9. | ALA3530304 | ADME | Activity of rat recombinant CYP3A1 expressed in baculovirus-infected insect cells assessed as enzyme-mediated N-((4-(4-fluorophenyl)-2-oxochroman-7-yl)methyl)-2-((S)-2-hydroxy-2-(trifluoromethyl)butanoyl)hydrazinecarboxamide formation preincubated for 3 mins by Michaelis-Menten equation in presence of NADPH for 10 mins | Rattus norvegicus | 1 | ALA3526019 | cell-based format | Scientific Literature | |
10. | ALA3530305 | ADME | Activity of rat recombinant CYP3A2 expressed in baculovirus-infected insect cells assessed as enzyme-mediated N-((4-(4-fluorophenyl)-2-oxochroman-7-yl)methyl)-2-((S)-2-hydroxy-2-(trifluoromethyl)butanoyl)hydrazinecarboxamide formation preincubated for 3 mins by Michaelis-Menten equation in presence of NADPH for 10 mins | Rattus norvegicus | 1 | ALA3526019 | cell-based format | Scientific Literature | |
11. | ALA3530466 | ADME | Drug metabolism in NADPH fortified rat liver microsomes assessed as N-((4-(4-fluorophenyl)-2-oxochroman-7-yl)methyl)-2-((S)-2-hydroxy-2-(trifluoromethyl)butanoyl)hydrazinecarboxamide level | Rattus norvegicus | 1 | ALA3526019 | assay format | Scientific Literature | |
12. | ALA4152533 | Binding | Inhibition of 5-LOX (unknown origin) | Homo sapiens | 4 | ALA4152186 | single protein format | Scientific Literature |