| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4310614 | B | Displacement of [3H]-DAMGO from recombinant human mu-opioid receptor expressed in CHOK1 cells | Homo sapiens | 21 | ALA4308867 | cell-based format | Scientific Literature | |
| 2. | ALA4310615 | B | Displacement of [3H]-DADLE from recombinant human delta-opioid receptor expressed in HEK293 cells | Homo sapiens | 21 | ALA4308867 | cell-based format | Scientific Literature | |
| 3. | ALA4310616 | A | Stability in human microsomes assessed as parent compound remaining at 0.5 uM measured after 0.5 hrs | Homo sapiens | 20 | ALA4308867 | microsome format | Scientific Literature | |
| 4. | ALA4310617 | A | Stability in rat microsomes assessed as parent compound remaining at 0.5 uM measured after 0.5 hrs | Rattus norvegicus | 20 | ALA4308867 | microsome format | Scientific Literature | |
| 5. | ALA4310618 | A | Total clearance in rat at 1 mg/kg, po administered as cassette dose | Rattus norvegicus | 20 | ALA4308867 | organism-based format | Scientific Literature | |
| 6. | ALA4310619 | A | Oral bioavailability in rat at 1 mg/kg administered as cassette dose | Rattus norvegicus | 20 | ALA4308867 | organism-based format | Scientific Literature | |
| 7. | ALA4310620 | A | Brain to blood partition coefficient, Kp of the compound in rat at 1 mg/kg, po administered as cassette dose | Rattus norvegicus | 18 | ALA4308867 | organism-based format | Scientific Literature | |
| 8. | ALA4310621 | A | Cmax in rat brain at 1 mg/kg, po administered as cassette dose | Rattus norvegicus | 20 | ALA4308867 | organism-based format | Scientific Literature | |
| 9. | ALA4310623 | P | Chemical stability of the compound | 14 | ALA4308867 | small-molecule physicochemical format | Scientific Literature | ||
| 10. | ALA4310624 | A | Stability in plasma (unknown origin) assessed as parent compound remaining after 24 hrs | Not specified | 16 | ALA4308867 | cell-free format | Scientific Literature | |
| 11. | ALA4310625 | F | Antagonist activity at mu-opioid receptor (unknown origin) by [35S]-GTPgammaS binding assay | Homo sapiens | 5 | ALA4308867 | single protein format | Scientific Literature | |
| 12. | ALA4310626 | F | Antagonist activity at delta-opioid receptor (unknown origin) by [35S]-GTPgammaS binding assay | Homo sapiens | 5 | ALA4308867 | single protein format | Scientific Literature | |
| 13. | ALA4310627 | F | In vivo antagonist activity at mu-opioid receptor in po dosed ferret assessed as inhibition of morphine-induced emesis/vomiting | Mustela putorius furo | 4 | ALA4308867 | organism-based format | Scientific Literature | |
| 14. | ALA4310629 | F | In vivo antagonist activity at delta-opioid receptor in po dosed rat assessed as inhibition of morphine-induced constipation | Rattus norvegicus | 4 | ALA4308867 | organism-based format | Scientific Literature | |
| 15. | ALA4310631 | F | Antianalgesic activity in po dosed rat assessed as inhibition of morphine-induced analgesia by tail-flick test | Rattus norvegicus | 5 | ALA4308867 | organism-based format | Scientific Literature | |
| 16. | ALA4310632 | F | Selectivity ratio of ED50 for inhibition of morphine-induced analgesia in po dosed rat to ED50 for inhibition of morphine-induced emesis/vomiting in po dosed ferret | 4 | ALA4308867 | organism-based format | Scientific Literature | ||
| 17. | ALA4310633 | F | Selectivity ratio of ED50 for inhibition of morphine-induced analgesia in po dosed rat to ED50 for inhibition of morphine-induced constipation in po dosed rat | Rattus norvegicus | 4 | ALA4308867 | organism-based format | Scientific Literature |
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