| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3539246 | ADME | Activity of human recombinant CYP2C9 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated 3-(2,4-dimethylphenylthio)-4-(piperazin-1-yl)phenol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 2. | ALA3539247 | ADME | Activity of human recombinant CYP2C19 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated 3-(2,4-dimethylphenylthio)-4-(piperazin-1-yl)phenol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 3. | ALA3539248 | ADME | Activity of human recombinant CYP1A2 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated 3-(2,4-dimethylphenylthio)-4-(piperazin-1-yl)phenol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 4. | ALA3539249 | ADME | Activity of human recombinant CYP2A6 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated 3-(2,4-dimethylphenylthio)-4-(piperazin-1-yl)phenol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 5. | ALA3539250 | ADME | Activity of human recombinant CYP2B6 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated 3-(2,4-dimethylphenylthio)-4-(piperazin-1-yl)phenol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 6. | ALA3539251 | ADME | Activity of human recombinant CYP2E1 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated 3-(2,4-dimethylphenylthio)-4-(piperazin-1-yl)phenol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 7. | ALA3539252 | ADME | Activity of human recombinant CYP3A4 expressed in microsomes isolated from human AHH-1 cells assessed as enzyme-mediated 3-(2,4-dimethylphenylthio)-4-(piperazin-1-yl)phenol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 8. | ALA3539253 | ADME | Activity of human recombinant FMO3 expressed in microsomes isolated from baculovirus infected insect BTI-TN-5B1-4 cells assessed as enzyme-mediated 3-(2,4-dimethylphenylthio)-4-(piperazin-1-yl)phenol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 9. | ALA3539254 | ADME | Drug metabolism in phenotyped human liver microsomes assessed as formation of (3-methyl-4-(2-(piperazin-1-yl)phenylthio)phenyl)methanol at 8 to 50 uM after 60 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | assay format | Scientific Literature | |
| 10. | ALA3539255 | ADME | Drug metabolism in phenotyped human liver microsomes assessed as formation of 3-methyl-4-(2-(piperazin-1-yl)phenylthio)benzoic acid at 8 to 50 uM after 60 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | assay format | Scientific Literature | |
| 11. | ALA3539256 | ADME | Drug metabolism in phenotyped human liver microsomes assessed as formation of 1-(2-(2,4-dimethylphenylsulfinyl)phenyl)piperazine at 8 to 50 uM after 60 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | assay format | Scientific Literature | |
| 12. | ALA3539257 | ADME | Drug metabolism in phenotyped human liver microsomes assessed as formation of 4-(2-(2,4-dimethylphenylthio)phenyl)piperazin-1-ol at 8 to 50 uM after 60 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | assay format | Scientific Literature | |
| 13. | ALA3539258 | ADME | Drug metabolism in phenotyped human liver microsomes assessed as formation of 3-(2,4-dimethylphenylthio)-4-(piperazin-1-yl)phenol at 8 to 50 uM after 60 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | assay format | Scientific Literature | |
| 14. | ALA3539260 | ADME | Activity of human recombinant FMO3 expressed in microsomes isolated from baculovirus infected insect BTI-TN-5B1-4 cells assessed as enzyme-mediated 1-(2-(2,4-dimethylphenylsulfinyl)phenyl)piperazine formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 15. | ALA3539565 | ADME | Activity of human recombinant FMO3 expressed in microsomes isolated from baculovirus infected insect BTI-TN-5B1-4 cells assessed as enzyme-mediated 4-(2-(2,4-dimethylphenylthio)phenyl)piperazin-1-ol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 16. | ALA3539566 | ADME | Activity of human recombinant FMO3 expressed in microsomes isolated from baculovirus infected insect BTI-TN-5B1-4 cells assessed as enzyme-mediated 3-methyl-4-(2-(piperazin-1-yl)phenylthio)phenyl)methanol formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 17. | ALA3539567 | ADME | Activity of human recombinant FMO3 expressed in microsomes isolated from baculovirus infected insect BTI-TN-5B1-4 cells assessed as enzyme-mediated 3-methyl-4-(2-(piperazin-1-yl)phenylthio)benzoic acid formation at 8 to 50 uM after 120 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | cell-based format | Scientific Literature | |
| 18. | ALA3540134 | ADME | Drug metabolism in pooled human liver microsomes assessed as formation of (3-methyl-4-(2-(piperazin-1-yl)phenylthio)phenyl)methanol at 100 uM after 30 to 180 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | assay format | Scientific Literature | |
| 19. | ALA3540135 | ADME | Drug metabolism in pooled human liver microsomes assessed as formation of 3-methyl-4-(2-(piperazin-1-yl)phenylthio)benzoic acid at 100 uM after 30 to 180 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | assay format | Scientific Literature | |
| 20. | ALA3540136 | ADME | Drug metabolism in pooled human liver microsomes assessed as formation of 1-(2-(2,4-dimethylphenylsulfinyl)phenyl)piperazine at 100 uM after 30 to 180 mins by HPLC/MS-MS analysis in presence of NADPH regenerating system with NADP+ | Homo sapiens | 1 | ALA3525899 | assay format | Scientific Literature |
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